Intra-individual comparison of ¹⁸F-FET and ¹⁸F-DOPA in PET imaging of recurrent brain tumors.
Intra-individual comparison of ¹⁸F-FET and ¹⁸F-DOPA in PET imaging of recurrent brain tumors.
复制标题
18F-FET 和 18F-DOPA 在复发性脑肿瘤 PET 成像中的个体内比较。
作者：
C. Kratochwil;S. Combs;K. Leotta;A. Afshar;S. Rieken;J. Debus;U. Haberkorn;F. Giesel
背景
（18）F-氟二羟基苯丙氨酸（18）F-DOPA）和（18）F-氟乙基酪氨酸（18）F-FET）已经成功地用于脑肿瘤的成像。本研究的目的是评价这两种有前途的示踪剂之间的差异，以确定成像协议的后果和结果的解释。
方法
对复发性低级别星形细胞瘤（n = 8）或高级别胶质母细胞瘤（n = 8）患者连续2天使用（18）F-DOPA和（18）F-FET进行40分钟的动态PET成像。分别分析了两种示踪剂的时间-活性曲线（TAC）、标准化摄取值（SUV）和房室模型。
结果
DOPA-PET的TAC在注射后8分钟达到峰值。在高级别胶质瘤中SUV为5.23，低级别胶质瘤的SUV为4.92 FET-PET在注射后9分钟达到峰值。在高级别胶质瘤中SUV为3.17，低级别胶质瘤的SUV为3.24忽略多巴胺进入纹状体的特异性摄取，DOPA-PET的肿瘤与脑和肿瘤与血液的比率较高。动力学模型表明，高流量常数k1（mL/ccm/min），代表细胞内化通过AS-转运蛋白，多巴在高级别（k1 = 0.59）和低级别（k1 = 0.55）肿瘤，而较低的绝对值和相关的依赖性从肿瘤分级（高级别k1 = 0.43;低级别k1 = 0.33），观察与FET。
结论
DOPA-PET显示纹状体外病变的上级对比度，但SUV与分级无关。FET-PET可以提供有关肿瘤分级的额外信息，并从较低的纹状体摄取中获益，但对比度较低，如果组织学无法提前获得，则需要延长成像时间，因为到达峰值的时间变化更大。
BACKGROUND
Both (18)F-fluorodihydroxyphenylalanine ((18)F-DOPA) and (18)F-fluoroethyltyrosine ((18)F-FET) have already been used successfully for imaging of brain tumors. The aim of this study was to evaluate differences between these 2 promising tracers to determine the consequences for imaging protocols and the interpretation of findings.
METHODS
Forty minutes of dynamic PET imaging were performed on 2 consecutive days with both (18)F-DOPA and (18)F-FET in patients with recurrent low-grade astrocytoma (n = 8) or high-grade glioblastoma (n = 8). Time-activity-curves (TACs), standardized uptake values (SUVs) and compartment modeling of both tracers were analyzed, respectively.
RESULTS
The TAC of DOPA-PET peaked at 8 minutes p.i. with SUV 5.23 in high-grade gliomas and 10 minutes p.i. with SUV 4.92 in low-grade gliomas. FET-PET peaked at 9 minutes p.i. with SUV 3.17 in high-grade gliomas and 40 minutes p.i. with SUV 3.24 in low-grade gliomas. Neglecting the specific uptake of DOPA into the striatum, the tumor-to-brain and tumor-to-blood ratios were higher for DOPA-PET. Kinetic modeling demonstrated a high flow constant k1 (mL/ccm/min), representing cellular internalization through AS-transporters, for DOPA in both high-grade (k1 = 0.59) and low-grade (k1 = 0.55) tumors, while lower absolute values and a relevant dependency from tumor-grading (high-grade k1 = 0.43; low-grade k1 = 0.33) were observed with FET.
CONCLUSIONS
DOPA-PET demonstrates superior contrast ratios for lesions outside the striatum, but SUVs do not correlate with grading. FET-PET can provide additional information on tumor grading and benefits from lower striatal uptake but presents lower contrast ratios and requires prolonged imaging if histology is not available in advance due to a more variable time-to-peak.
卡比多巴给药对正电子发射断层扫描中 6-[18F]氟-L-多巴动力学的影响。
DOI：
--
发表时间：
1992
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Hoffman,JM;Melega,WP;Hawk,TC;Grafton,SC;Luxen,A;Mahoney,DK;Barrio,JR;Huang,SC;Mazziotta,JC;Phelps,ME
通讯作者：
Phelps,ME