Insights on synaptic paired-pulse response using parametric and non-parametric models.
Insights on synaptic paired-pulse response using parametric and non-parametric models.
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DOI：
10.1109/embc.2013.6609682
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Berger TW
中科院分区：
文献类型：
--
作者：
Bouteiller JM;Hu E;Allam SL;Ghaderi V;Song D;Berger TW
配对脉冲协议是一种成熟的刺激模式，用于表征突触效力的短期变化。由于实验难以获取和测量亚突触元素之间的反应和相互作用，理解形成突触反应的机制极具挑战性。我们已经建议解决这个问题，并使用一个名为EONS（神经系统基本对象）的复杂集成建模平台来深入了解这个问题。这个参数化平台的使用为我们提供了关于亚突触成分以及它们的相互作用如何形成突触动力学的深刻信息。在此，我们建议添加并结合一个非参数模型来(i)简化建模框架，基本参数的数量和总体计算复杂性，同时忠实地保持理想的突触行为；（ii）提供一个清晰简洁的框架来表征AMPA和NMDA对观察到的配对脉冲响应的贡献。
Paired-pulse protocol is a well-established stimulation pattern used to characterize short-term changes in synaptic potency. Due to the experimental difficulty in accessing and measuring responses and interactions between subsynaptic elements, understanding the mechanisms that shape synaptic response is extremely challenging. We already proposed to address this issue and gain insights on the matter using a complex integrated modeling platform called EONS (Elementary Objects of the Nervous System). The use of this parametric platform provided us with insightful information on the subsynaptic components and how their interactions shape synaptic dynamics. We herein propose to add and combine a non-parametric model to (i) simplify the modeling framework, the number of underlying parameters and the overall computational complexity while faithfully maintaining the desirable synaptic behavior and (ii) provide a clear and concise framework to characterize AMPA and NMDA contributions to the observed paired-pulse responses.