Cadmium levels in the blood of inhabitants in nonpolluted areas in Japan with special references to aging and smoking.
Cadmium levels in the blood of inhabitants in nonpolluted areas in Japan with special references to aging and smoking.
复制标题
日本无污染地区居民血液中的镉含量，特别是衰老和吸烟。
DOI：
10.1016/0013-9351(83)90025-7
复制
发表时间：
1983
影响因子：
8.3
通讯作者：
M. Ikeda
中科院分区：
文献类型：
--
作者：
T. Watanabe;A. Koizumi;H. Fujita;M. Kumai;M. Ikeda
血液样本，2259在冬季和523在其他季节的一年中，收集了全国范围内的居民（主要是农民）在没有已知的人为污染的地区，并分析镉。该水平呈对数正态分布，在年轻人中较低，并逐渐增加，在40-59岁年龄组达到稳定水平，其中女性的值（几何平均值约为3.6 ng/ml）显著高于男性（3.0-3.4 ng/ml）。在40-59岁年龄段内，夫妻双方均为非吸烟者，对77对水平进行比较，性别差异仍为正（P< 0.01）。吸烟习惯会增加血液中的镉含量。这种增加是剂量依赖性的，高达20-29支/天，并随着进一步消费而趋于平稳。被动吸烟的影响无法证实。血镉水平的季节性变化可以忽略不计。该国不同地理位置的水平差异的重要性令人怀疑。两种途径的镉剂量估计比例，即，通过胃肠道和通过肺，与非吸烟者血镉水平的比例和吸烟导致的水平额外增加一致。
Blood samples, 2259 in winter and 523 in other seasons of the year, were collected nationwide in Japan from inhabitants (primarily farmers) in areas with no known man-made pollution, and analyzed for cadmium. The levels were distributed log normally, and were lower among young adults and increased gradually to reach a plateau at the 40–59 age group, where the values in females (about 3.6 ng/ml as a geometric mean) were significantly higher than in males (3.0–3.4 ng/ml). The sex difference was positive (P< 0.01) even when 77 pairs of levels were compared between husbands and their wives, both being nonsmokers in the age range of 40–59 years. Smoking habits gave an additional increase in the blood cadmium level. The increase was dose dependent up to 20–29 cigarettes/day and leveled off with further consumption. Effects of passive smoking could not be confirmed. Seasonal variation in blood cadmium level appeared negligible. Variation in the level by geographic location in the country was of doubtful significance. The estimated ratio of cadmium doses by two routes, i.e., via the gastrointestinal tract and via the lungs, was in agreement with the ratio of the blood cadmium level among nonsmokers and the additional increase in the level due to smoking.