The dark side of antiviral T cell responses.
The dark side of antiviral T cell responses.
复制标题
抗病毒 T 细胞反应的阴暗面。
DOI：
10.1038/s41593-019-0454-8
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发表时间：
2019
影响因子：
25
通讯作者：
Rosi,Susanna
中科院分区：
文献类型：
--
作者：
Krukowski,Karen;Rosi,Susanna
蚊子传播的病毒感染，如西尼罗河病毒和寨卡病毒，会导致认知能力下降，即使脑炎痊愈，这种影响也会持续存在。Garber等人通过病毒特异性介导的小胶质突触消除，确定了感染恢复后抗病毒T细胞持续存在导致认知损伤的机制。
Mosquito-borne virus infections, such as West Nile and Zika, have debilitating cognitive effects that persist despite recovery from encephalitis. Garber et al. identify mechanisms by which antiviral T cell persistence after recovery from infection leads to impairments in cognition via virus-specific mediation of microglial synapse elimination.