Prematurity and cardiovascular risk at early adulthood.
Prematurity and cardiovascular risk at early adulthood.
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DOI：
10.1111/cch.12616
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Msall ME
中科院分区：
文献类型：
--
作者：
Sullivan MC;Winchester SB;Msall ME
早期压力暴露和非稳态负荷理论提供了一个生命周期的角度来看，成人健康早产后，这些早期压力影响内分泌和代谢系统。在这项研究中，我们通过比较两组经历了全方位新生儿疾病的早产儿和23岁的足月出生组来检查心血管和代谢风险。在出生时招募的215名婴儿中，（84%）在23岁时参与。该队列包括45名足月（FT），24名健康早产儿（HPT）和111名患病早产儿（SPT）。社会经济地位（SES）在各组之间是相等的。心血管和代谢结局包括：血压（BP）、空腹血糖和血脂、体重、腰臀比（WHR）和体重指数（BMI）。比较新生儿组和性别的临床和亚临床范围。在23岁时，HPT和SPT组的收缩压高于FT组。与FT和HPT组相比，SPT组的体重较低。舒张压、血糖、总胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯、体重指数或腰臀比无组间差异。早产儿男性比FT男性有更多的收缩期高血压和低HDL。在23岁时，前早产男性和女性的WHR比值和BMI较高。HPT女性组的亚临床高血压前期发生率最高，其次是SPT女性。仅1例（4.2%）HPT成年男性为临床糖尿病。作为年轻人，HPT和SPT婴儿有心血管风险的早期指标，但没有代谢风险的指标。使用临床和亚临床范围来识别成年早期的早期心血管风险是有用的。
Theories of early stress exposure and allostatic load offer a lifespan perspective to adult health after prematurity based on these early stressors affecting endocrine and metabolic systems. In this study, we examine cardiovascular and metabolic risk by comparing two groups of preterm infants who experienced a full spectrum of neonatal illness and a term-born group at age 23. Of the 215 infants recruited at birth, (84%) participated at age 23. The cohort included 45 full term (FT), 24 healthy preterm (HPT), and 111 sick preterm (SPT) infants. Socioeconomic status (SES) was equivalent across groups. Cardiovascular and metabolic outcomes were: blood pressure (BP), fasting glucose and lipid profiles, weight, waist-hip ratio (WHR), and body mass index (BMI). Clinical and sub-clinical ranges were compared across neonatal groups and gender. At age 23, the HPT and SPT groups had higher systolic BP compared to the FT group. The SPT group had lower weight compared to the FT and HPT groups. No group differences were found on diastolic BP, glucose, total cholesterol, HDL, LDL, triglycerides, BMI or WHR. Preterm males had more systolic hypertension and low HDL than FT males. Former preterm males and females had high WHR ratios and BMI at 23 years. Subclinical pre-hypertensive rates were highest for the HPT female group, followed by the SPT females. Only one (4.2%) HPT adult male was clinically diabetic. As young adults, HPT and SPT infants had early indicators of cardiovascular risk, but no indicators of metabolic risk. There is utility in using clinical and sub-clinical ranges to identify early cardiovascular risk in early adulthood.
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影响因子：
16.2
作者：
Kajantie E;Osmond C;Barker DJ;Eriksson JG
通讯作者：
Eriksson JG
影响因子：
8.3
作者：
Hovi, Petteri;Vohr, Betty;Kajantie, Eero
通讯作者：
Kajantie, Eero
影响因子：
4.4
作者：
Kerr-Wilson, C. O.;Mackay, D. F.;Pell, J. P.
通讯作者：
Pell, J. P.
影响因子：
158.5
作者：
Hovi, Petteri;Andersson, Sture;Kajantie, Eero
通讯作者：
Kajantie, Eero
影响因子：
2.5
作者：
Holsti, L;Grunau, RE;Whitfield, MF
通讯作者：
Whitfield, MF