Electroconvulsive Therapy Stimulus Dose Expressed as Volume of Seizure Foci
Electroconvulsive Therapy Stimulus Dose Expressed as Volume of Seizure Foci
复制标题
以癫痫病灶体积表示的电惊厥治疗刺激剂量
DOI：
10.1097/00124509-200603000-00012
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
C. Swartz
中科院分区：
文献类型：
--
作者：
C. Swartz
电刺激剂量通常表示为以毫库仑（mC）为单位的电荷，代表电子的数量。然而，由于忽略了神经元去极化的电压阈值，单独的电荷是不合适的。随着时间的推移，任何电荷都可以从亚阈值电压累积。刺激能量表示热含量;没有输送率，它与去极化电压无关。目的是根据癫痫发作诱导生理学制定刺激剂量。方法刺激剂量用所产生的癫痫灶体积表示，这是一个依赖于电流和电荷的变量。第二个更详细的模型认为脑电压与临床深部脑刺激有关。结果美国常用刺激器的恒流刺激特性，刺激剂量与电流的立方乘以电荷成正比。这种关系对应于空间中的电压场的3维，其中在一定电压以上的体积随着电压半径的立方而增加。因此，0.9 A（安培）电流下的任何特定电荷的癫痫灶剂量比0.8 A电流下的相同电荷高约50%。结论模型提供了一个解释发表的测量比较仪器的最大电流0.8和0.9 A。建模还建议补偿方法应用于基于年龄的双边刺激给药方法。基于“半龄”（2.5 mC/y）的电给药策略对于0.9-A刺激是合理的，但“四分之三龄”（3.7 mC/y）更适合0.8-A刺激。目前的结果可以允许剂量和癫痫发作阈值之间进行比较不同的电流，当一个电休克治疗仪器替代另一个。
Background Electrical stimulus dose is typically stated as charge in millicoulombs (mC), representing the number of electrons. However, by overlooking the voltage threshold for neuronal depolarization, charge alone is inappropriate. Any charge can accumulate from subthreshold voltage over time. Stimulus energy represents heat content; without a delivery rate, it is not related to depolarization voltage. The objective was to formulate stimulus dose in accordance with seizure induction physiology. Method Stimulus dose was expressed as volume of generated seizure foci, a variable dependent on current and charge. A second more detailed model considers brain voltages as related to clinical deep brain stimulation. Results For the constant current stimuli characteristic of widely available American stimulators, stimulus dose is proportional to current cubed multiplied by charge. This relationship corresponds to the 3 dimensions of a voltage field in space, where the volume above a certain voltage increases with the cube of the voltage radius. As a consequence, any particular charge at 0.9 A (ampere) current has a seizure foci dose approximately 50% higher than the same charge at 0.8 A. Conclusions The modeling offers an explanation for published measurements comparing instruments of maximum current 0.8 and 0.9 A. The modeling also suggests compensation approaches to be applied to the age-based bilateral stimulus dosing method. An electrical dosing strategy based on "half-age" (2.5 mC/y) is reasonable for 0.9-A stimulation but a "three-quarters age" (3.7 mC/y) is more appropriate for 0.8-A stimulation. The present results can allow doses and seizure thresholds to be compared between different currents, as when substituting one electroconvulsive therapy instrument for another.
影响因子：
158.5
作者：
SACKEIM, HA;PRUDIC, J;SETTEMBRINO, JM
通讯作者：
SETTEMBRINO, JM
ECT 刺激的物理特性和量化：I. 基本原理。
DOI：
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发表时间：
1994
期刊：
Convulsive therapy
影响因子：
--
作者：
Sackeim,HA;Long,J;Luber,B;Moeller,JR;Prohovnik,I;Devanand,DP;Nobler,MS
通讯作者：
Nobler,MS
影响因子：
--
作者：
Sackeim, HA;Prudic, J;Clark, J
通讯作者：
Clark, J