Muscle Quality As a Potential Explanation of the Metabolically Healthy but Obese and Sarcopenic Obese Paradoxes
Muscle Quality As a Potential Explanation of the Metabolically Healthy but Obese and Sarcopenic Obese Paradoxes
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DOI：
10.1089/met.2011.0092
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发表时间：
2012-04-01
影响因子：
2.1
通讯作者：
Aubertin-Leheudre, Mylene
中科院分区：
文献类型：
--
作者：
Barbat-Artigas, Sebastien;Filion, Marie-Eve;Aubertin-Leheudre, Mylene
背景：肥胖与代谢并发症有关。然而，具有低肌肉质量的肥胖个体的两个亚组（即“肌肉减少性肥胖”和“代谢健康但肥胖”个体）似乎具有更好的代谢概况。尽管有较低的肌肉质量，这些人似乎有较高的肌肉力量，这表明更高的肌肉质量。研究报告胰岛素敏感性与肌肉质量有关。因此，本研究的目的是检验这一假设，即低肌肉质量与更好的肌肉质量在肥胖individual.Methods：共112绝经后妇女年龄在50和77岁（平均值，61 +/- 6年）被招募。身体成分（生物电阻抗），肌肉力量（手部测力计）和功能能力结果：正常体重时，骨骼肌质量（SM; kg）与肌力（kg）呈显著正相关（r = 0.43; P = 0.003）和超重（r = 0.42; P = 0.020）妇女，但不存在肥胖（r = 0.28; P = 0.13）妇女。正常体重（r =-0.41，P = 0.005）、超重（r = -0.59，P = 0.001）和肥胖（r =-0.59，P = 0.001）个体的肌肉质量（kg）与肌肉质量（kg/SMkg）呈显著负相关。正常体重（r =-0.33，P = 0.025）、超重（r =-0.47，P = 0.008）和肥胖（r =-0.43，P = 0.015）女性的骨骼肌质量指数（kg/m2）与肌肉质量呈显著负相关。最后，II型sarcopenic个人有较高的肌肉质量比I型sarcopenic（P = 0.002）和nonsarcopenic（P = 0.001）individual.Conclusions：我们的研究结果支持我们的假设，并表明，肌肉质量增加，肌肉质量和肌肉质量指数下降。因此，肌肉质量可能潜在地解释了在代谢健康但肥胖和肌肉减少性肥胖的绝经后妇女中观察到的有利的代谢特征。需要进一步的研究，包括代谢数据来证实我们的结果。
Background: Obesity has been associated with metabolic complications. However, two subgroups of obese individuals (namely "sarcopenic obese" and "metabolically healthy but obese" individuals) with low muscle mass appear to have a better metabolic profile. Despite having a lower muscle mass, these individuals appear to have higher muscle strength, suggesting higher muscle quality. Studies have reported insulin sensitivity to be related to muscle quality. Therefore, the aim of the present study was to test the hypothesis that low muscle mass was associated with better muscle quality in obese individuals.Methods: A total of 112 postmenopausal women aged between 50 and 77 years (means, 61 +/- 6 years) were recruited. Body composition (bioelectrical impedancemetry), muscle strength (hand dynamometer), and functional capacity (chair stand test, alternate step test and balance test) were measured.Results: Skeletal muscle mass (SM; kg) was significantly positively correlated with muscle strength (kg) in normal weight (r = 0.43; P = 0.003) and overweight (r = 0.42; P = 0.020) women, but not in obese (r = 0.28; P = 0.13) women. Muscle mass (kg) was significantly negatively correlated with muscle quality (kg/SMkg) in normal weight (r = -0.41, P = 0.005), overweight (r = -0.59; P < 0.001) and obese (r = -0.59; P < 0.001) individuals. Skeletal muscle mass index (kg/m(2)) was significantly negatively correlated with muscle quality in normal weight (r = -0.33, P = 0.025), overweight (r = -0.47, P = 0.008), and obese (r = -0.43, P = 0.015) women. Finally, type II sarcopenic individuals had higher muscle quality than type I sarcopenic (P = 0.002) and nonsarcopenic (P = 0.001) individuals.Conclusions: Our results support our hypothesis and showed that muscle quality increased as muscle mass and muscle mass index decreased. Thus, muscle quality may potentially explain the favorable metabolic profile observed in metabolically healthy but obese and sarcopenic obese postmenopausal women. Further studies including metabolic data are needed to confirm our results.