Role of TH-17 cells in rheumatic and other autoimmune diseases.
Role of TH-17 cells in rheumatic and other autoimmune diseases.
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DOI：
10.4172/2161-1149.1000104
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发表时间：
2011-10
期刊：
影响因子：
5.5
通讯作者：
M. Volin;S. Shahrara
中科院分区：
文献类型：
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作者：
M. Volin;S. Shahrara
在人类中，多种途径可以诱导TH-17细胞分化，而在小鼠中，该过程主要由IL-6和TGF-β调节。TH-17细胞产生的IL-17与许多炎性自身免疫性疾病相关，包括银屑病、系统性红斑狼疮、炎性肠病、多发性硬化和类风湿性关节炎。本文就TH-17细胞/IL-17在类风湿关节炎和实验性关节炎发病机制中的作用作一综述。TH-17细胞在类风湿性关节炎进展中的潜在作用已经通过将TH-17细胞百分比或IL-17水平与类风湿性关节炎疾病活动评分和C-反应蛋白水平相关联来证明。此外，先前的研究表明，IL-17介导的血管化可能为类风湿性关节炎关节中性粒细胞和单核细胞募集以及软骨和骨破坏奠定基础。IL-17在实验性关节炎发病中的重要作用可能与其与TNF-α和IL-1 β的协同作用有关。虽然使用抗IL-17抗体的初步临床试验对类风湿性关节炎有希望，但未来的人类研究将进一步阐明抗IL-17治疗如何影响类风湿性关节炎和其他自身免疫性疾病的发病机制。
In humans multiple pathways can induce TH-17 cell differentiation, whereas in mice this process is mostly modulated by IL-6 and TGF-β. IL-17 produced by TH-17 cells has been associated with a number of inflammatory autoimmune diseases including psoriasis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, and rheumatoid arthritis. In this review, we have primarily focused on the role of TH-17 cells/IL-17 in the pathogenesis of rheumatoid arthritis and experimental arthritis. The potential role of TH-17 cells in rheumatoid arthritis progression has been demonstrated by correlating the percent TH-17 cells or levels of IL-17 with rheumatoid arthritis disease activity score and C-reactive protein levels. Further, previous studies suggest that IL-17 mediated vascularization may lay the foundation for rheumatoid arthritis joint neutrophil and monocyte recruitment as well as cartilage and bone destruction. The profound role of IL-17 in the pathogenesis of experimental arthritis may be due to its synergistic effect with TNF-α and IL-1β. Although the initial clinical trial employing anti-IL-17 antibody has been promising for rheumatoid arthritis, future studies in humans will shed more light on how anti-IL-17 therapy affects rheumatoid arthritis and other autoimmune disease pathogenesis.