Questions and answers on iron deficiency treatment selection and the use of intravenous iron in routine clinical practice.
Questions and answers on iron deficiency treatment selection and the use of intravenous iron in routine clinical practice.
复制标题
DOI：
10.1080/07853890.2020.1867323
复制
发表时间：
2021-12
影响因子：
4.4
通讯作者：
Weiss G
中科院分区：
文献类型：
--
作者：
Richards T;Breymann C;Brookes MJ;Lindgren S;Macdougall IC;McMahon LP;Munro MG;Nemeth E;Rosano GMC;Schiefke I;Weiss G
缺铁治疗的选择是由几个因素驱动的，包括炎症的存在，补铁的时间，以及副作用或不耐受的预期风险。静脉内铁制剂适用于口服制剂无效或无法使用时的铁缺乏症治疗，因此适用于广泛的临床环境，包括慢性炎症性疾病、围手术期环境和与慢性失血相关的疾病。可以根据通常发生的时间预测静脉铁剂发生的不良事件，这为教育和准备工作人员和患者如何安全有效地进行铁剂输注提供了基础。缺铁是一种常见的发病原因，可作为许多疾病的后果或并发症出现。在过去十年中，静脉铁剂的使用显著增加，但对适应症和管理的担忧仍然存在。现代静脉内铁制剂可以促进一次或两次剂量的快速铁补充，用于绝对铁缺乏和在存在炎症的情况下功能性铁缺乏，其中口服铁治疗无效或不起作用。一个多学科的专家团队在缺铁方面经验丰富，进行了一项共识审查，以支持医疗保健专业人员在胃肠道，肾脏和心脏疾病以及妊娠，月经大出血和手术中管理缺铁方面的实用建议。我们解释静脉铁剂如何在口服铁剂不能起作用的地方起作用。我们提供了关于静脉铁剂应如何以及何时施用的背景，以及关于潜在益处与潜在副作用平衡的知情意见。我们提出了如何静脉注射铁的副作用，可以预期的条款，他们可能是什么，当他们可能发生。这一共识的目的是提供一个实际的基础，教育和准备工作人员和患者何时以及如何铁输注可以安全有效地管理。
Iron deficiency treatment selection is driven by several factors, including the presence of inflammation, the time available for iron replenishment, and the anticipated risk of side-effects or intolerance. Intravenous iron preparations are indicated for the treatment of iron deficiency when oral preparations are ineffective or cannot be used, and therefore have applicability in a wide range of clinical contexts, including chronic inflammatory conditions, perioperative settings, and disorders associated with chronic blood loss. Adverse events occurring with intravenous iron can be anticipated according to when they typically occur, which provides a basis for educating and preparing staff and patients on how iron infusions can be administered safely and efficiently. Iron deficiency is a common cause of morbidity and can arise as a consequence or complication from many diseases. The use of intravenous iron has increased significantly in the last decade, but concerns remain about indications and administration. Modern intravenous iron preparations can facilitate rapid iron repletion in one or two doses, both for absolute iron deficiency and, in the presence of inflammation, functional iron deficiency, where oral iron therapy is ineffective or has not worked. A multidisciplinary team of experts experienced in iron deficiency undertook a consensus review to support healthcare professionals with practical advice on managing iron deficiency in gastrointestinal, renal and cardiac disease, as well as; pregnancy, heavy menstrual bleeding, and surgery. We explain how intravenous iron may work where oral iron has not. We provide context on how and when intravenous iron should be administered, and informed opinion on potential benefits balanced with potential side-effects. We propose how intravenous iron side-effects can be anticipated in terms of what they may be and when they may occur. The aim of this consensus is to provide a practical basis for educating and preparing staff and patients on when and how iron infusions can be administered safely and efficiently.
登录
查看更多内容
影响因子：
8
作者：
Dignass, Axel U.;Gasche, Christoph;Vavricka, Stephan
通讯作者：
Vavricka, Stephan
影响因子：
18.2
作者：
Anker, Stefan D.;Kirwan, Bridget-Anne;Ponikowski, Piotr
通讯作者：
Ponikowski, Piotr
影响因子：
5.9
作者：
Barton, JC;Barton, EH;Sherrer, JS
通讯作者：
Sherrer, JS
影响因子：
2.6
作者：
Bircher, Andreas J.;Auerbach, Michael
通讯作者：
Auerbach, Michael
DOI：
10.1016/j.ejogrb.2010.02.030
发表时间：
2010-06-01
影响因子：
2.6
作者：
Bergmann, Renate L.;Richter, Rolf;Dudenhausen, Joachim W.
通讯作者：
Dudenhausen, Joachim W.