Depressive symptoms and AIDS-related mortality among a multisite cohort of HIV-positive women
Depressive symptoms and AIDS-related mortality among a multisite cohort of HIV-positive women
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DOI：
10.2105/ajph.94.7.1133
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发表时间：
2004-07-01
影响因子：
12.7
通讯作者：
Hessol, NA
中科院分区：
文献类型：
--
作者：
Cook, JA;Grey, D;Hessol, NA
目标.在控制了抗逆转录病毒治疗的使用、心理健康治疗、药物依从性、药物滥用、临床指标和人口统计学因素后，我们研究了抑郁症状与艾滋病相关死亡率之间的关系。1994年至2001年，有1 716名艾滋病毒血清反应呈阳性的妇女每半年到6个地点的诊所就诊。多变量考克斯和逻辑回归分析估计了艾滋病相关死亡时间和抑郁症状严重程度。在我们控制了所有其他因素后，艾滋病相关的死亡更可能发生在有慢性抑郁症状的女性中，并且在疾病的晚期阶段，症状更严重。精神卫生服务的使用与死亡率降低相关。抑郁症的治疗是艾滋病毒血清阳性妇女，特别是那些患有终末期疾病的妇女的全面护理的一个至关重要的组成部分。
Objectives. We examined associations between depressive symptoms and AIDS-related mortality after controlling for antiretroviral therapy use, mental health treatment, medication adherence, substance abuse, clinical indicators, and demographic factors.Methods. One thousand seven hundred sixteen HIV-seropositive women completed semiannual visits from 1994 through 2001 to clinics at 6 sites. Multivariate Cox and logistic regression analyses estimated time to AIDS-related death and depressive symptom severity.Results. After we controlled for all other factors, AIDS-related deaths were more likely among women with chronic depressive symptoms, and symptoms were more severe among women in the terminal phase of their illness. Mental health service use was associated with reduced mortality.Conclusions. Treatment for depression is a critically important component of comprehensive care for HIV-sero positive women, especially those with end-stage disease.