A trivial role of STAT4 variant in chronic hepatitis B induced hepatocellular carcinoma
A trivial role of STAT4 variant in chronic hepatitis B induced hepatocellular carcinoma
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DOI：
10.1016/j.meegid.2013.05.025
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发表时间：
2013-08-01
影响因子：
3.2
通讯作者：
Velavan, Thirumalaisamy P.
中科院分区：
文献类型：
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作者：
Clark, Adam;Gerlach, Franziska;Velavan, Thirumalaisamy P.
STAT4和HLADQ两个基因座的两个多态与慢性乙型肝炎(CHB)诱导的肝细胞癌(HCC)相关。我们使用了一个独立的越南队列，对慢性乙肝携带者(n=206)、肝硬变(n=222)和肝细胞癌(n=239)的临床分类的乙肝患者进行了研究，并评估了所报道的变异的影响。在等位基因和隐性遗传模型中，STAT4基因突变(Rs7574865)与慢性乙肝携带者的肝癌易感性有一定关联(OR=0.84，95%CI=0.7~0.99，P=0.048和OR=0.7，95%CI=0.5~0.99，P=0.047)。未观察到该变异与肝酶(ALT、AST)、总胆红素和直接胆红素、甲胎蛋白、HBV型和病毒载量等几个临床参数之间的显著关联。我们的研究强调，报道的变异是一个微不足道的因素，可能还有其他混杂因素可能在肝细胞癌发展过程中调节STAT4的表达。(C)2013爱思唯尔B.V.保留所有权利。
Two polymorphisms in the STAT4 and HLA-DQ loci were more recently reported to associate with chronic hepatitis B (CHB) induced hepatocellular carcinoma (HCC). We utilised an independent Vietnamese cohort of clinically classified HBV patients of chronic hepatitis B carriers (n = 206), liver cirrhosis (n = 222) and hepatocellular carcinoma (n = 239) and assessed the influence of the reported variants. The STAT4 variant (rs7574865) was marginally associated with HCC susceptibility in CHB carriers in allelic and recessive genetic models (OR = 0.84, 95%CI = 0.7-0.99, P = 0.048 and OR = 0.7, 95%CI = 0.5-0.99, P = 0.047). No significant association between the studied variant with several clinical parameters such as liver enzymes (ALT, AST), total and direct bilirubin, AFP, HBV genotype and viral loads were observed. Our study highlights the reported variant to be a trivial factor and possibly other confounding factors may regulate STAT4 expression during HCC development. (c) 2013 Elsevier B.V. All rights reserved.