The Hanes-Woolf linear QUESP method improves the measurements of fast chemical exchange rates with CEST MRI.
The Hanes-Woolf linear QUESP method improves the measurements of fast chemical exchange rates with CEST MRI.
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DOI：
10.1002/mrm.24792
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发表时间：
2014-04
影响因子：
3.3
通讯作者：
Pagel, Mark D.
中科院分区：
文献类型：
--
作者：
Randtke, Edward A.;Chen, Liu Qi;Corrales, L. Rene;Pagel, Mark D.
用于化学交换饱和转移（CEST）MRI的造影剂通常需要精确测量化学交换速率。已经报道了许多测量化学交换率的分析方法。作为本研究的一部分，衍生了其他分析方法。本报告研究了每种分析方法的准确度和精密度。CEST光谱使用针对化学交换修改的Bloch-McConnell方程进行模拟。碘普罗胺的CEST光谱是在一系列饱和时间、饱和功率和浓度下获得的。这些模拟和实验结果用于使用QUESP、QUEST、Omega Plot（LB-QUESP）、EH-QUESP、HW-QUESP、LB-Conc、EH-Conc和HW-Conc方法估计化学交换速率。布洛赫拟合产生了最精确的估计化学交换率，虽然大量的专业知识和计算时间需要实现这些结果。在较为简单的分析方法中，HW-QUESP方法对快速汇率的估计最为准确和精确。QUEST和LB-QUESP方法产生了最准确的慢交换率估计，特别是具有短T1 w弛豫时间的样品。HW-QUESP是一种简单的分析方法，当需要根据CEST MRI结果估计快速化学交换率时，应使用该方法。
Contrast agents for Chemical Exchange Saturation Transfer (CEST) MRI often require an accurate measurement of the chemical exchange rate. Many analysis methods have been reported that measure chemical exchange rates. Additional analysis methods were derived as part of this study. This report investigated the accuracy and precision of each analysis method. CEST spectra were simulated using the Bloch-McConnell equations modified for chemical exchange. CEST spectra of iopromide were obtained with a range of saturation times, saturation powers, and concentrations. These simulated and experimental results were used to estimate the chemical exchange rate using the QUESP, QUEST, Omega Plot (LB-QUESP), EH-QUESP, HW-QUESP, LB-Conc, EH-Conc, and HW-Conc methods. Bloch fitting produced the most precise estimates of chemical exchange rates, although substantial expertise and computation time were required to achieve these results. Of the more simplistic analysis methods, the HW-QUESP method produced the most accurate and precise estimates of fast exchange rates. The QUEST and LB-QUESP methods produced the most accurate estimates of slow exchange rates, especially with samples that have short T1w relaxation times. HW-QUESP is a simplistic analysis method that should be used when fast chemical exchange rates need to be estimated from CEST MRI results.
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影响因子：
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作者：
Li Y;Sheth VR;Liu G;Pagel MD
通讯作者：
Pagel MD
影响因子：
2.2
作者：
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通讯作者：
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影响因子：
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影响因子：
3.3
作者：
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通讯作者：
Sun, Phillip Zhe
影响因子：
2.2
作者：
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通讯作者：
Chappell, M. A.