Rat muscle blood flows as a function of time during prolonged slow treadmill exercise.
Rat muscle blood flows as a function of time during prolonged slow treadmill exercise.
复制标题
在长时间缓慢的跑步机运动过程中，大鼠肌肉血流量随时间变化。
DOI：
10.1152/ajpheart.1983.244.6.h814
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Armstrong,RB
中科院分区：
文献类型：
--
作者：
Laughlin,MH;Armstrong,RB
这些实验的目的是跟踪在长时间的低速跑步机运动中，大鼠后肢骨骼肌内和之间的血流量(BF)作为时间的函数。雄性SD大鼠长期使用两根硅胶导管，一根在升主动脉经右颈动脉注入微球，另一根在左肾动脉取动脉参考血样。采用放射性标记微球技术，在运动前和15m/min跑台运动时，分别于运动前、运动0.5、1、5、15、30、54和71min测量大鼠23块主要骨骼肌内和肌间的血流量。在运动前，深度慢抽动肌肉的BF最高(210毫升)。Min-1。股中间肌100g~(-1))。在第一分钟的运动中，后肢的每一块肌肉都表现出四种常见的BF模式之一。1)前30天S运动时，BF中有许多肌肉出现“超调”；2)前30天S运动时，部分肌肉达到稳定运动水平；3)部分肌肉运动后低于运动前水平；4)部分肌肉运动前无变化。从运动5min到54min，大部分肌肉的BF逐渐增加。运动前BF的升高主要针对反重力伸肌中快速抽动的氧化肌纤维，伸肌组的BF普遍高于屈肌组。数据表明，无论是在运动前还是在长时间的低强度跑步机步行至疲劳期间，大鼠肌肉内和肌肉之间的BF都是不同的。调节流向肌肉的血流分布的机制仍有待阐明。
The purpose of these experiments was to follow blood flows (BF) within and among rat hindlimb skeletal muscles as a function of time during prolonged low-speed treadmill locomotion. Male Sprague-Dawley rats were chronically instrumented with two Silastic catheters, one in the ascending aorta via the right carotid artery for microsphere infusion and one in the left renal artery for arterial reference blood sample withdrawal. BFs were measured, using the radio-labeled microsphere technique, within and among 23 major skeletal muscles of rats before exercise and during treadmill locomotion at 15 m/min at 0.5, 1, 5, 15, 30, 54, and 71 min of exercise. During preexercise, BF was highest to deeply situated slow-twitch muscles (210 ml . min-1 . 100 g-1 in vastus intermedius) in the antigravity extensor muscle groups. During the 1st min of exercise each of the hindlimb muscles displayed one of four general BF patterns. 1) Many muscles had an “overshoot” in BF during the first 30 s of exercise; 2) some muscles attained steady-state exercise levels in the first 30 s of exercise; 3) others showed a decrease below preexercise levels; and 4) some muscles showed no change from preexercise. Most muscles showed a gradual increase in BF from 5 min through 54 min of exercise. The elevations in BF over preexercise were primarily directed to fast-twitch oxidative muscle fibers in the antigravity extensor muscles, and BFs to extensor muscle groups were generally higher than those to flexor muscle groups. The data demonstrate that BFs within and among rat muscles are heterogeneous, both before exercise and during prolonged low-intensity treadmill walking to fatigue. Mechanisms regulating the distribution of flow to the muscles remain to be elucidated.