IMMUNOSUPPRESSION IN PREGNANT-WOMEN INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS
IMMUNOSUPPRESSION IN PREGNANT-WOMEN INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS
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DOI：
10.1016/0002-9378(89)90674-1
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发表时间：
1989-11-01
影响因子：
9.8
通讯作者：
GOEDERT, JJ
中科院分区：
文献类型：
--
作者：
BIGGAR, RJ;PAHWA, S;GOEDERT, JJ
对102例高危感染人类免疫缺陷病毒的孕妇（62例为药物滥用者，40例为海地籍）在妊娠期间和妊娠后进行了前瞻性免疫学检查。在63名人类免疫缺陷病毒阴性的妇女中，CD 4+（辅助）细胞水平在分娩前8周降至最低点，并在分娩前迅速上升。从妊娠中期到分娩，CD 8+（细胞毒性/抑制）细胞水平缓慢上升。在37名人类免疫缺陷病毒阳性孕妇中，CD 4+细胞水平在怀孕期间下降（除了分娩前短暂的微弱上升），在产后期间没有恢复。人类免疫缺陷病毒阳性妇女的CD 8+细胞水平始终高于人类免疫缺陷病毒阴性妇女。HIV阴性妇女产后CD 8+细胞稳定在分娩水平，而HIV阳性妇女产后CD 8+细胞大幅增加。人类免疫缺陷病毒阳性妇女的CD 4+细胞损失似乎在怀孕期间比产后更快。这些数据支持这一假设，即妊娠可能加速人类免疫缺陷病毒诱导的CD 4+细胞耗竭，并增加获得性免疫缺陷综合征的风险。
One hundred two pregnant women at high risk of infection with the human immunodeficiency virus (62 who were drug abusers and 40 of Haitian origin) were prospectively examined for immunologic changes during and after pregnancy. Among the 63 human immunodeficiency virus-negative women, levels of CD4+ (helper) cells fell to a nadir at 8 weeks before delivery and rose rapidly just before delivery. The level of CD8+ (cytotoxic/suppressor) cells rose slowly from midpregnancy to delivery. Among the 37 human immunodeficiency virus-positive pregnant women, levels of CD4+ cells fell during pregnancy (except for a transient weak increase just before delivery) and did not recover in the postpartum period. Levels of CD8+ cells were consistently higher in human immunodeficiency virus-positive than human immunodeficiency virus-negative women. Post partum the CD8+ cells in human immunodeficiency virus-negative women stabilized at delivery levels, whereas they increased greatly in human immunodeficiency virus-positive women. The loss of CD4+ cells in human immunodeficiency virus-positive women appeared to be faster during pregnancy than in the postpartum period. These data support the hypothesis that pregnancy may accelerate human immunodeficiency virus-induced depletion of CD4+ cells and increase the risk of acquired immunodeficiency syndrome.