Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan
Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan
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DOI：
10.1111/j.1872-034x.2007.00043.x
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发表时间：
2007-04-01
影响因子：
4.2
通讯作者：
Onji, Morikazu
中科院分区：
文献类型：
--
作者：
Matsuura, Kana;Michitaka, Kojiro;Onji, Morikazu
目的：D基因型B型肝炎病毒（HBV/D）在日本很少见，但在日本西部的爱媛县流行。HBV/D被怀疑是由于日俄战争而从俄罗斯转移到爱媛县的。本研究探讨了目前的地理传播和感染途径的HBV/D在爱媛县。方法：HBV基因型确定为508例慢性HBV感染和46例急性HBV感染性肝炎（急性肝炎，AH），所有这些人都住在爱媛县。结果：慢性感染者中A、B、C、D基因型分别占1.8%、4.5%、87.8%、5.9%。HBV/D慢性感染者多居住在中心城区。仅2例患者居住在东部和西南部地区，且均在童年时期居住在中部地区。AH患者，由于HBV/D被发现只在中央area.Conclusion：HBV/D尚未广泛传播到其他地区比中央爱媛县，虽然少数感染者已转移到其他地区。无论HBV基因型如何，AH患者的主要感染途径是性传播。
Aims: Hepatitis B virus genotype D (HBV/D) is rare in Japan, and has been shown to circulate in Ehime prefecture in western Japan. HBV/D is suspected to have been transferred into Ehime from Russia as a result of the Japanese-Russian War. This study examined the current geographic spread and infectious route for HBV/D in Ehime.Methods: HBV genotype was determined for 508 patients with chronic HBV infection and 46 patients with acute HBV infection hepatitis (acute hepatitis, AH), all of whom were living in Ehime. Ehime was divided into three areas and genotypic distributions were studied.Results: The ratio of genotypes A,B,C and D in chronically infected patients were 1.8%, 4.5%, 87.8% and 5.9%, respectively. Most patients chronically infected with HBV/D lived in the central area. Only two patients lived in the east and south-west areas, and both had lived in the central area in childhood. Patients with AH due to HBV/D were found only in the central area.Conclusion: HBV/D has not yet spread widely to areas other than central Ehime, although small numbers of infected people have moved to other areas. The major infectious route for patients with AH is sexual transmission, regardless of HBV genotype.