Predictors of survival for younger patients less than 50 years of age with non-small cell lung cancer (NSCLC): A California Cancer Registry analysis
Predictors of survival for younger patients less than 50 years of age with non-small cell lung cancer (NSCLC): A California Cancer Registry analysis
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DOI：
10.1016/j.lungcan.2014.04.007
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发表时间：
2014-08-01
期刊：
影响因子：
5.3
通讯作者：
Kelly, Karen
中科院分区：
文献类型：
--
作者：
Lara, Matthew S.;Brunson, Ann;Kelly, Karen
背景：非小细胞肺癌（NSCLC）在50岁以下的患者中很少被诊断出来。我们分析了加州癌症登记处（CCR），以描述该患者亚组的流行病学特征和结局，并确定病因特异性生存率（CSS）的预后因素。方法：纳入1998年1月1日至12月31日诊断为NSCLC并报告至2011年10月（CCR）的患者。主要结局指标为CSS。考克斯回归模型用于评估年轻NSCLC患者CSS的预测因子，并对潜在混杂因素进行校正。年龄组（≥ 50岁）和特定的人口统计学和肿瘤协变量之间进行交互分析。结果：我们确定了132，671例肺癌病例，其中114，451例（86.3%）为NSCLC。其中，6389人（5.6%）
Background: Non-small cell lung cancer (NSCLC) is uncommonly diagnosed in patients younger than 50 years of age. We analyzed the California Cancer Registry (CCR) to describe epidemiologic characteristics and outcomes in this patient subset and to identify factors prognostic for cause-specific survival (CSS).Methods: Patients diagnosed with NSCLC between 1/1/98 through 12/31/09 and reported to the (CCR) as of October 2011 were included. The primary outcome measure was CSS. Cox regression models were used to evaluate predictors of CSS in young patients with NSCLC, adjusted for potential confounders. Interaction analysis was performed between age groups (= 50) and specific demographic and tumor covariates.Results: We identified 132,671 lung cancer cases, of which 114,451 (86.3%) had NSCLC. Of these, 6389 (5.6%) were