Survival and transmission of community-associated methicillin-resistant Staphylococcus aureus from fomites
Survival and transmission of community-associated methicillin-resistant Staphylococcus aureus from fomites
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DOI：
10.1016/j.ajic.2010.07.005
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发表时间：
2011-04-01
影响因子：
4.9
通讯作者：
Miller, Loren G.
中科院分区：
文献类型：
--
作者：
Desai, Rishi;Pannaraj, Pia S.;Miller, Loren G.
背景资料：社区相关耐甲氧西林金黄色葡萄球菌（CA-MRSA）从污染物传播似乎在CA-MRSA暴发中起重要作用。然而，MRSA的传播的量和持续时间还没有被quantitatived.Methods：我们评估的CA-MRSA菌株USA 300 -0114从9 fomites（剃须刀，塑料玩具，陶瓷，肥皂，木材，乙烯基，毛巾，床单，和垫肩）的生存和传输。将污染物接种，然后在5分钟时短暂按压到无菌猪皮上;第1、2、3、7和10天;然后每周一次，持续10周。结果：除肥皂外，所有污染物均能将细菌传播至皮肤，其中2株为甲氧西林敏感金黄色葡萄球菌（MSSA），3株为卫生保健相关MRSA（HA）。随着时间的推移，传染性下降，但更迅速地从多孔（如毛巾）比无孔（如乙烯基）污染物（P = 0.0002），与一些污染物显示传染性超过8周后污染。CA-MRSA株的传播时间明显长于HA-MRSA株（P <0.0001）和1株MSSA株。结论：CA-MRSA株可从多种污染物传播至皮肤，污染的无孔污染物在污染后数周内仍表现出传播性。与CA-MRSA菌株相比，HA-MRSA菌株的传播性表现出减弱的传播性。研究结果可能对CA-MRSA感染预防有影响。
Background: Transmission of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) from fomites appears to play an important role in CA-MRSA outbreaks. However, the amount and duration of transmissibility of MRSA have not been quantified.Methods: We assessed the survival and transmission of the CA-MRSA strain USA300-0114 from 9 fomites (razors, plastic toys, ceramic, soap, wood, vinyl, towels, bed sheets, and shoulder pads). Fomites were inoculated then briefly pressed onto sterile pigskin at 5 minutes; days 1, 2, 3, 7, and 10; and then weekly for 10 weeks. The experiment was repeated using 2 methicillin-susceptible S aureus (MSSA) and 3 health care-associated (HA) MRSA strains on select fomites.Result: Bacteria could be transmitted to skin from all fomites except soap. Transmissibility decreased over time but more rapidly from porous (eg, towels) than nonporous (eg, vinyl) fomites (P = .0002), with some fomites showing transmissibility for more than 8 weeks after contamination. The CA-MRSA strain was transmissible longer than the HA-MRSA strains (P < .0001) and 1 MSSA strain.Conclusion: CA-MRSA strains are transmissible from many fomites to skin with contaminated nonporous fomites exhibiting transmissibility many weeks after contamination. Transmissibility of HA-MRSA strains demonstrated attenuated transmissibility compared with CA-MRSA strains. Findings may have implications for CA-MRSA infection prevention.