Regulation of biomechanical signals by NF-κB transcription factors in chondrocytes
Regulation of biomechanical signals by NF-κB transcription factors in chondrocytes
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DOI：
10.3233/bir-2008-0472
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发表时间：
2008-01-01
期刊：
影响因子：
1.1
通讯作者：
Agarwal, Sudha
中科院分区：
文献类型：
--
作者：
Anghelina, Mirela;Sjostrom, Danen;Agarwal, Sudha
审查的目的。物理治疗和锻炼不仅有利于发炎或受伤关节的生理恢复，而且有利于促进健康关节的体内平衡。人体关节提供了枢轴点和生理铰链，对于身体的运动和运动至关重要，并且这种移动性反过来促进了关节的健康。但是，动员如何在分子水平上调节关节微环境多年来一直是个谜。关节生物力学和分子方法的最新进展促进了对关节如何运作的丰富理解。因此，在体内动物模型中以及在体外细胞和组织水平上，导致关节炎病症的关节炎症期间的活性机制已经变得越来越详细和明确。这些努力已经产生了越来越多的证据，支持生物力学信号在关节炎疾病的发病机制和关节的生理恢复中起着重要作用的前提。本报告旨在总结当前的同行评审文献和可用的实验数据，以解释机械力/关节动员产生的信号如何对发炎的关节软骨产生有益的影响，并提出使用适当的物理治疗的基础，以使关节相关损伤患者获得最佳益处。
Purpose of review. Physical therapies and exercise are beneficial not only for physiological recovery in inflamed or injured joints, but also for promoting a homeostatic equilibrium in healthy joints. Human joints provide the pivot points and physiological hinges essential for ambulation and movement to the body, and it is this mobility that in return promotes the health of the joints. But how mobilization regulates the joint microenvironment at the molecular level has remained enigmatic for many years. Recent advances in joint biomechanics and molecular approaches have facilitated an enriched understanding of how joints operate. Consequently, the mechanisms active during joint inflammation that lead to arthritic conditions, both in vivo in animal models, and in vitro at cell and tissue levels, have become increasingly detailed and defined. These efforts have produced mounting evidences supporting the premise that biomechanical signals play a fundamental role in both the etiopathogenesis of arthritic diseases and in the physiological restoration of joints. This report aims to summarize current peer-reviewed literature and available experimental data to explain how the signals generated by mechanical forces/joint mobilization generate beneficial effects on inflamed articular cartilage, and to propose the basis for using appropriate physical therapies for the optimal benefit to the patient suffering from joint associated injuries.