CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies.
CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies.
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CpG寡脱氧核苷酸纳米药物用于预防或治疗癌症，传染病和过敏。
DOI：
10.2147/ijn.s114477
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发表时间：
2017
影响因子：
8
通讯作者：
Hanagata N
中科院分区：
文献类型：
--
作者：
Hanagata N
含有未甲基化胞嘧啶-鸟嘌呤二核苷酸的寡脱氧核苷酸 (CpG ODN) 是 Toll 样受体 9 (TLR9) 的合成激动剂，可激活体液和细胞免疫，并被开发为预防或治疗癌症、传染病和过敏的疫苗佐剂。游离 CpG ODN 已用于许多临床试验以验证其效果。然而，最近的研究报道，自组装 CpG ODN、蛋白质/肽-CpG ODN 缀合物和纳米材料-CpG ODN 复合物表现出比游离 CpG ODN 更高的佐剂效应，因为它们提高了表达 TLR9 的细胞的摄取效率。此外，蛋白质/肽-CpG ODN缀合物和纳米材料-CpG ODN复合物能够将CpG ODN和抗原（或过敏原）递送至相同类型的细胞，从而实现更高程度的预防或治疗效果。在这篇综述中，作者描述了包含自组装CpG ODN、蛋白质/肽-CpG ODN缀合物和纳米材料-CpG ODN复合物的CpG ODN纳米药物的研究和开发的最新趋势，重点关注临床前和临床研究的结果。
Unmethylated cytosine-guanine dinucleotide-containing oligodeoxynucleotides (CpG ODNs), which are synthetic agonists of Toll-like receptor 9 (TLR9), activate humoral and cellular immunity and are being developed as vaccine adjuvants to prevent or treat cancers, infectious diseases, and allergies. Free CpG ODNs have been used in many clinical trials implemented to verify their effects. However, recent research has reported that self-assembled CpG ODNs, protein/peptide–CpG ODN conjugates, and nanomaterial–CpG ODN complexes demonstrate higher adjuvant effects than free CpG ODNs, owing to their improved uptake efficiency into cells expressing TLR9. Moreover, protein/peptide–CpG ODN conjugates and nanomaterial–CpG ODN complexes are able to deliver CpG ODNs and antigens (or allergens) to the same types of cells, which enables a higher degree of prophylaxis or therapeutic effect. In this review, the author describes recent trends in the research and development of CpG ODN nanomedicines containing self-assembled CpG ODNs, protein/peptide–CpG ODN conjugates, and nanomaterial–CpG ODN complexes, focusing mainly on the results of preclinical and clinical studies.