Deriving, regenerating, and engineering CNS tissues using human pluripotent stem cells.
Deriving, regenerating, and engineering CNS tissues using human pluripotent stem cells.
复制标题
使用人类多能干细胞衍生、再生和改造中枢神经系统组织。
DOI：
10.1016/j.copbio.2017.05.010
复制
发表时间：
2017
影响因子：
7.7
通讯作者：
Ashton,RandolphS
中科院分区：
文献类型：
--
作者：
Lemke,KristenA;Aghayee,Alireza;Ashton,RandolphS
摘要发育生物学原理可用于产生多种CNS细胞类型。多种CNS细胞疗法的临床试验正在进行或即将进行。2-和3-D CNS组织模型扩大了临床相关性的范围。从人多能干细胞中获得中枢神经系统细胞表型谱的进展刺激了神经系统疾病体外建模和再生疗法开发的重大进展。虽然这些进展的临床影响仍在评估中，但它们与先进的组织工程方法和诱导神经回路可塑性的治疗方法的整合仍然是未被探索的前沿。
HighlightsDevelopmental biology principles can be applied to generate diverse CNS cell types.Clinical trials for diverse CNS cell therapies are either ongoing or imminent.2-and 3-D CNS tissue models expand the scope of clinical relevance.Progress in deriving a spectrum of central nervous system cell phenotypes from human pluripotent stem cells has spurred significant advances in in vitro modeling and development of regenerative therapies for neurological disorders. While the clinical impact of these advances is still being evaluated, their integration with advanced tissue engineering methodologies and therapeutic approaches that induce neural circuit plasticity, respectively, remain underexplored frontiers.