Sudden cardiac arrest associated with early repolarization
Sudden cardiac arrest associated with early repolarization
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DOI：
10.1056/nejmoa071968
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发表时间：
2008-05-08
影响因子：
158.5
通讯作者：
Clementy, Jacques
中科院分区：
文献类型：
--
作者：
Haissaguerre, Michel;Derval, Nicolas;Clementy, Jacques
背景：早期复极是一种常见的心电图表现，通常被认为是良性的。它的潜在原因心律失常已被假设从实验研究，但它是不知道是否有一个临床关联与心脏骤停.Methods：我们回顾了206例受试者在22个中心谁是复苏后，由于特发性室颤心脏骤停的数据，并评估了心电图早期复极的患病率。后者定义为下方或外侧导联的QRS-ST交界处较基线升高至少0.1 mV，表现为QRS模糊或切迹。对照组包括412名没有心脏病的受试者，他们的年龄，性别，种族和体力活动水平相匹配。结果：特发性室颤患者早期复极发生率高于对照组（31%比5%，P
Background: Early repolarization is a common electrocardiographic finding that is generally considered to be benign. Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is not known whether there is a clinical association with sudden cardiac arrest.Methods: We reviewed data from 206 case subjects at 22 centers who were resuscitated after cardiac arrest due to idiopathic ventricular fibrillation and assessed the prevalence of electrocardiographic early repolarization. The latter was defined as an elevation of the QRS-ST junction of at least 0.1 mV from baseline in the inferior or lateral lead, manifested as QRS slurring or notching. The control group comprised 412 subjects without heart disease who were matched for age, sex, race, and level of physical activity. Follow-up data that included the results of monitoring with an implantable defibrillator were obtained for all case subjects.Results: Early repolarization was more frequent in case subjects with idiopathic ventricular fibrillation than in control subjects (31% vs. 5%, P