2 TNF RECEPTORS

2 TNF RECEPTORS
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DOI:
10.1016/0167-5699(92)90116-o
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发表时间:
1992-05-01
期刊:
IMMUNOLOGY TODAY
影响因子:
--
通讯作者:
GOEDDEL, DV
GOEDDEL, DV
中科院分区:
其他
文献类型:
--
作者:
TARTAGLIA, LA;GOEDDEL, DV

文献摘要

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在过去的几年里,肿瘤坏死因子受体的鉴定和特性研究取得了长足的进展。这两种受体在信号转导肿瘤坏死因子不同功能中所起的相对作用还不是很清楚。在这里,Louis Taraglia和David Goeddel总结了迄今为止的研究进展,并提出了一个肿瘤坏死因子受体触发的模型,该模型协调了看似相互矛盾的数据。
In the past few years, considerable progress has been made on the identification and characterization of tumor necrosis factor (TNF) receptors. The relative roles played by the two receptor types in signaling the diverse functions of TNF are less clear. Here, Louis Tartaglia and David Goeddel summarize progress to date and propose a model of TNF receptor triggering that reconciles the seemingly conflicting data.