Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells
Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells
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DOI：
10.1016/j.phymed.2015.10.016
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发表时间：
2016-10-15
期刊：
影响因子：
7.9
通讯作者：
Eid, Ali H.
中科院分区：
文献类型：
--
作者：
Al-Shehabi, Tuqa Saleh;Iratni, Rabah;Eid, Ali H.
背景：心血管疾病（CVD）仍然是全球死亡的主要原因，其中动脉粥样硬化是造成这种死亡的主要原因。该疾病的发病机制涉及多种机制。动脉粥样硬化病变发生和进展的关键因素是血管平滑肌细胞的表型。在损伤等病理生理条件下，这些细胞从收缩性转变为合成表型，通常具有高增殖和迁移能力。 目的：尽管在动脉粥样硬化的管理和治疗方面取得了重大进展，但与这种疾病相关的死亡率仍然很高。这就要求寻求其他方法。草药，特别是用于治疗心血管疾病的草药，近年来受到越来越多的关注。这在很大程度上是由于与许多植物的消费相关的循证价值，以及相对便宜的价格、更容易获得和世代相传的传统民间医学。章节：在这篇综述中，我们简要介绍了动脉粥样硬化的发病机制，然后我们强调了血管平滑肌细胞在这种疾病中的作用，特别是当这些细胞发生表型转换时。然后，我们深入讨论了具有抗动脉粥样硬化潜在有益作用的各种植物，重点关注抑制血管平滑肌细胞表型转换的草药和植物。结论：不断积累的证据为使用植物药治疗或预防动脉粥样硬化提供了理由。然而，需要进一步的研究，特别是临床研究，以更好地确定这些草药的几个药理学参数，例如毒性、耐受性和功效。 (C) 2015 爱思唯尔有限公司。版权所有。
Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. A key element in the development and progression of atherosclerotic lesions is the phenotype of vascular smooth muscle cells. Under pathophysiologic conditions such as injury, these cells switch from a contractile to a synthetic phenotype that often possesses high proliferative and migratory capacities.Purpose: Despite major advances made in the management and treatment of atherosclerosis, mortality associated with this disease remains high. This mandates that other approaches be sought. Herbal medicine, especially for the treatment of CVD, has been gaining more attention in recent years. This is in no small part due to the evidence-based values associated with the consumption of many plants as well as the relatively cheaper prices, easier access and conventional folk medicine "inherited" over generations.Sections: In this review, we provide a brief introduction about the pathogenesis of atherosclerosis then we highlight the role of vascular smooth muscle cells in this disease, especially when a phenotypic switch of these cells arises. We then thoroughly discuss the various plants that show potentially beneficial effects as anti-atherosclerotic, with prime attention given to herbs and plants that inhibit the phenotypic switch of vascular smooth muscle cells.Conclusion: Accumulating evidence provides the justification for the use of botanicals in the treatment or prevention of atherosclerosis. However, further studies, especially clinical ones, are warranted to better define several pharmacological parameters of these herbs, such as toxicity, tolerability, and efficacy. (C) 2015 Elsevier GmbH. All rights reserved.