Heritability of left ventricular structure and function in Caucasian families
Heritability of left ventricular structure and function in Caucasian families
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DOI：
10.1093/ejechocard/jer019
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发表时间：
2011-04-01
影响因子：
--
通讯作者：
Staessen, Jan A.
中科院分区：
文献类型：
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作者：
Jin, Yu;Kuznetsova, Tatiana;Staessen, Jan A.
目的-本研究的目的是调查的遗传力以及遗传和环境的相关性左心室（LV）的结构和功能性状在复杂的家系的高加索population.Methods和结果我们随机招募了459白色欧洲受试者从52个家庭（50%的妇女，平均年龄45岁）。用M型和二维超声心动图测量左室结构，用常规多普勒和组织多普勒成像（TDI）测量左室功能。其他测量包括血压、人体测量和生化测量。我们估计了左心室性状的遗传力，同时调整了协变量，包括性别、年龄、身高和体重、收缩压和舒张压以及心率。经完全校正后，左室质量的遗传度为0.23（P = 0.025）。TDI衍生的二尖瓣环速度Ea和Aa显示出中等遗传性（h（2）= 0.36和0.53，分别），而二尖瓣流入A峰具有弱遗传性（h（2）= 0.25），E峰不具有遗传性（h（2）= 0.11）。我们将总的表型相关性划分为遗传和环境两个部分。E峰与Ea峰的遗传相关系数为0.61，A峰与Aa峰的遗传相关系数为0.90。结论左室质量、二尖瓣环Ea峰和Aa峰的遗传力中等。我们还发现了显着的遗传相关性之间的E和Ea峰和之间的A和Aa峰。我们目前的研究结果支持正在进行的研究，以映射和检测遗传变异，有助于LV质量和其他LV结构和功能表型的变化。
Aims The aim of this study was to investigate the heritability as well as genetic and environmental correlations of left ventricular (LV) structural and functional traits in complex pedigrees of a Caucasian population.Methods and results We randomly recruited 459 white European subjects from 52 families (50% women; mean age 45 years). LV structure was measured by M-mode and 2D echocardiography and LV function was measured by conventional Doppler and tissue Doppler imaging (TDI). Other measurements included blood pressure, anthropometric, and biochemical measurements. We estimated the heritability of LV traits while adjusting for covariables, including sex, age, body height and weight, systolic and diastolic blood pressures, and heart rate. With full adjustment, heritability of LV mass was 0.23 (P = 0.025). The TDI-derived mitral annular velocities Ea and Aa showed moderate heritability (h(2) = 0.36 and 0.53, respectively), whereas the mitral inflow A peak had weak heritability (h(2) = 0.25) and the E peak was not heritable (h(2) = 0.11). We partitioned the total phenotypic correlation when it reached significance, into a genetic and an environmental component. The genetic correlations were 0.61 between the E and Ea peaks and 0.90 between the A and Aa peaks.Conclusion Our study demonstrated moderate heritability for LV mass as well as the mitral annular Ea and Aa peaks. We also found significant genetic correlations between the E and Ea peaks and between the A and Aa peaks. Our current findings support the ongoing research to map and detect genetic variants that contribute to the variation in LV mass and other LV structural and functional phenotypes.