Biophysical Model of Bacterial Cell Interactions with Nanopatterned Cicada Wing Surfaces
Biophysical Model of Bacterial Cell Interactions with Nanopatterned Cicada Wing Surfaces
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DOI：
10.1016/j.bpj.2012.12.046
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发表时间：
2013-02-19
影响因子：
3.4
通讯作者：
Ivanova, Elena P.
中科院分区：
文献类型：
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作者：
Pogodin, Sergey;Hasan, Jafar;Ivanova, Elena P.
Clanger Clanger（Psaltoda claripennis）翅膀表面的纳米图案代表了一类新的生物材料的第一个例子，这种生物材料可以仅仅基于它们的物理表面结构在接触时杀死细菌。机翼为开发新型功能表面提供了一个模型，这些功能表面具有增强的抗细菌污染和感染能力。我们提出了一个生物物理模型之间的相互作用的细菌细胞和机翼表面结构，并表明，机械性能，特别是细胞的刚度，是决定细菌的耐药性/敏感性的翅膀表面的杀菌性质的关键因素。我们通过微波照射细胞降低表面抗性菌株的刚性，使它们容易受到翅膀效应的影响，从而在实验上证实了这一点。我们的研究结果证明了将翼纳米粒子纳入抗菌纳米材料设计的潜在好处。
The nanopattern on the surface of Clanger cicada (Psaltoda claripennis) wings represents the first example of a new class of biomaterials that can kill bacteria on contact based solely on their physical surface structure. The wings provide a model tor the development of novel functional surfaces that possess an increased resistance to bacterial contamination and infection. We propose a biophysical model of the interactions between bacterial cells and cicada wing surface structures, and show that mechanical properties, in particular cell rigidity, are key factors in determining bacterial resistance/sensitivity to the bactericidal nature of the wing surface. We confirmed this experimentally by decreasing the rigidity of surface-resistant strains through microwave irradiation of the cells, which renders them susceptible to the wing effects. Our findings demonstrate the potential benefits of incorporating cicada wing nanopatterns into the design of antibacterial nanomaterials.