Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila
Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila
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DOI：
10.1016/j.cell.2008.03.034
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发表时间：
2008-05-30
期刊：
影响因子：
64.5
通讯作者：
Gould, Alex P.
中科院分区：
文献类型：
--
作者：
Maurange, Cedric;Cheng, Louise;Gould, Alex P.
在发育结束时终止细胞增殖的时间机制尚不清楚。在果蝇中枢神经系统中，被称为神经母细胞的单个祖细胞已知表达一系列转录因子，赋予子神经元不同的时间身份。在这里，我们发现Castor和Seven-Up，这个时间序列的成员，在晚期神经发生过程中调节许多不同神经母细胞谱系的关键事件。首先，他们安排了涉及目标Chinmo和Broad复合体的细胞大小和神经元身份的转换。其次，它们调节成神经细胞经历prospero依赖性细胞周期退出或Reaper/Hid/ grim依赖性细胞凋亡的时间。这两种类型的祖细胞终止都需要时间序列的后期和通过Castor靶（如Grainyhead和Dichaete）的间接前馈的联合作用。这些研究确定了终止中枢神经系统增殖的时间机制，并揭示了衰老祖细胞如何将转录因子的爆发转化为细胞增殖和细胞身份的长期变化。
The timing mechanisms responsible for terminating cell proliferation toward the end of development remain unclear. In the Drosophila CNS, individual progenitors called neuroblasts are known to express a series of transcription factors endowing daughter neurons with different temporal identities. Here we show that Castor and Seven-Up, members of this temporal series, regulate key events in many different neuroblast lineages during late neurogenesis. First, they schedule a switch in the cell size and identity of neurons involving the targets Chinmo and Broad Complex. Second, they regulate the time at which neuroblasts undergo Prospero-dependent cell-cycle exit or Reaper/Hid/Grim-dependent apoptosis. Both types of progenitor termination require the combined action of a late phase of the temporal series and indirect feedforward via Castor targets such as Grainyhead and Dichaete. These studies identify the timing mechanism ending CNS proliferation and reveal how aging progenitors transduce bursts of transcription factors into long-lasting changes in cell proliferation and cell identity.