Hemorrhagic fever with renal syndrome in the Dolenjska region of Slovenia -: A 10-year survey
Hemorrhagic fever with renal syndrome in the Dolenjska region of Slovenia -: A 10-year survey
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DOI：
10.1086/515185
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发表时间：
1999-04-01
影响因子：
11.8
通讯作者：
Lundkvist, Å
中科院分区：
文献类型：
--
作者：
Avsic-Zupanc, T;Petrovec, M;Lundkvist, Å
本报告描述了第一次调查的临床表现为一个较大的系列肾综合征出血热（HFRS）患者感染Dobrava病毒。从1985年至1995年，斯洛文尼亚Dolenjska地区Novo梅斯托的地区医院收治了38名经血清学确诊的HFRS患者。根据血清学检查结果，24名患者感染了Dobrava病毒，14名患者感染了Puumala病毒。31例患者的完整临床数据可用。11例患者接受血液透析治疗急性少尿或无尿肾功能衰竭。四名患者都感染了多布拉瓦病毒，有休克和严重出血的迹象。三名重症多布拉瓦病毒感染患者死于出血性并发症。我们已经证明，Dobrava和Puumala病毒共存于一个单一的地方性地区，能够引起严重程度有显着差异的HFRS。
This report describes the first investigation of clinical findings for a larger series of patients with hemorrhagic fever with renal syndrome (HFRS) who were infected with Dobrava virus. From 1985 to 1995, 38 patients with serologically confirmed HFRS were hospitalized at the regional hospital in Novo mesto in the Dolenjska region of Slovenia. On the basis of results of serological examination, 24 patients had Dobrava virus infection, and 14 patients had Puumala virus infection. Complete clinical data were available for 31 patients. Eleven patients underwent hemodialysis for treatment of acute oliguric or anuric renal failure. Four patients, all infested by Dobrava virus, had signs of shock and severe bleeding. Three severely ill Dobrava virus-infected patients died of hemorrhagic complications. We have demonstrated that Dobrava and Puumala viruses coexist in a single region of endemicity and are capable of causing HFRS with significant differences in severity.