A comprehensive linkage analysis for myocardial infarction and its related risk factors
A comprehensive linkage analysis for myocardial infarction and its related risk factors
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DOI：
10.1038/ng827
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发表时间：
2002-02-01
期刊：
影响因子：
30.8
通讯作者：
Schunkert, H
中科院分区：
文献类型：
--
作者：
Broeckel, U;Hengstenberg, C;Schunkert, H
冠状动脉疾病和心肌梗塞（MI）是西方世界的主要死亡原因。许多研究表明，糖尿病、高血压和高胆固醇血症等危险因素会导致这种疾病的发展。虽然每个风险因素本身部分受遗传控制，但阳性家族史是一个独立的预测因子，这表明还有其他易感基因（1）。我们扫描了513个家庭的全基因组，以确定与心肌梗死相关的染色体区域以及已知受遗传控制的相关风险因素。在此，我们通过方差分量分析和合并危险因素，显示心肌梗死的风险映射到14号染色体上的一个区域，其显著lod得分为3.9（逐点P=0.00015，全基因组P =0.00015）。
Coronary artery disease and myocardial infarction (MI) are leading causes of death in the western world. Numerous studies have shown that risk factors such as diabetes mellitus, arterial hypertension and hypercholesterolemia contribute to the development of the disease. Although each risk factor by itself is partly under genetic control, a positive family history is an independent predictor, which suggests that there are additional susceptibility genes(1). We have scanned the whole genome in 513 families to identify chromosomal regions linked to myocardial infarction and related risk factors that are known to be under genetic control. Here we show, by using variance component analysis and incorporating risk factors, that risk of myocardial infarction maps to a single region on chromosome 14 with a significant lod score of 3.9 (pointwise P=0.00015, genome-wide P