<i>In vivo</i> Assessment of Tissue Compatibility of Root Canal Sealer Containing Surface Pre-reacted Glass-ionomer Fillers
<i>In vivo</i> Assessment of Tissue Compatibility of Root Canal Sealer Containing Surface Pre-reacted Glass-ionomer Fillers
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含有表面预反应玻璃离子聚合物填料的根管封闭剂的组织相容性体内评估
DOI：
10.11471/odep.2022-005
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Nishida Erika,
中科院分区：
文献类型：
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作者：
Tanaka Saori;Miyaji Hirofumi;Mayumi Kayoko;Kanemoto Yukimi;Nishida Erika,
目的：表面预反应玻璃离子（S-PRG）填料具有释放氟离子、锶离子和硼酸根离子的性质，并表现出生物活性。在这项研究中，我们评估了体内临床前的影响，含S-PRG填料（S-PRG填料）。具体而言，我们评估了根尖周组织的炎症反应，使用S-PRG的根充，相比，密封剂与其他主要成分（矿物三氧化物聚合物（MTA），树脂，和noneugenol-氧化锌（ZO））。材料和方法：在全身麻醉和局部麻醉下，前磨牙牙髓切除术进行了10个月大的比格犬。根管预备、清洁和干燥后，通过应用各种密封剂和牙胶母尖进行根充。放射学分析根尖周透亮，组织学分析炎性细胞浸润伴骨吸收的区域。将根尖周组织对S-PRG糊剂的炎症反应与临床使用的封闭剂（包括MTA（Pro Root MTA）、树脂（AH Plus）和ZO（Canals N））的炎症反应进行比较。结果：所有实验组在1个月时均可见根尖周透亮。然而，在6个月时，根管N的根尖周透亮线持续存在，但其他三种填充物的根尖周透亮线不常见。在1个月的组织切片中，所有组显示出相似水平的炎性细胞浸润到邻近根尖孔的牙周组织中。6个月后，除Canals N外，所有封闭剂的牙周组织炎症反应均显著改善（p <0.05）。结论：S-PRG封闭剂在根尖周组织的炎症反应轻于Canals N。在根尖周区域愈合方面，S-PRG糊剂可提供与临床常用的Pro Root MTA和AH Plus相当的生物相容性。
Purpose: Surface pre-reacted glass-ionomer (S-PRG) fillers possess properties of releasing ions such as fluoride, strontium, and borate ions, and exhibit bioactive effects. In this study, we assessed the in vivo preclinical effect of a sealer containing S-PRG filler (S-PRG sealer). Specifically, we evaluated the inflammatory response of periapical tissues to the use of S-PRG sealer in root filling, compared to that of sealers with other main components (mineral trioxide aggregate (MTA), resin, and noneugenol-zinc oxide (ZO)).Materials and Methods: Under general and local anesthesia, premolar pulpectomies were performed in 10-month-old beagle dogs. After root canal preparation, cleaning, and drying, root filling was performed by applying various sealers with gutta-percha master points. Periapical lucency was analyzed radiographically, and the area of inflammatory cell infiltration with bone resorption was analyzed histologically. The inflammatory response of periapical tissues to S-PRG sealer was compared to those of clinically used sealers including MTA (Pro Root MTA), resin (AH Plus), and ZO (Canals N). Tissue specimens were prepared at 1 month and 6 months after obturation.Results: Periapical lucency was observed at 1 month in all groups. However, at 6 months, periapical lucency persisted with Canals N, but was infrequent with the other three fillers. In histological sections at 1 month, all groups showed similar levels of infiltration of inflammatory cells into the periodontal tissues adjacent to the root apical foramen. After 6 months, inflammation of the periodontal tissues was significantly improved (p< 0.05) for all sealers except for Canals N.Conclusion: The inflammatory response to S-PRG sealer at periapical tissues was milder than that to Canals N. The S-PRG sealer may provide biocompatibility comparable with that of commonly and clinically used Pro Root MTA and AH Plus in the healing of the periapical region.