Arterial baroreceptor reflex function in borderline hypertensive rats.
Arterial baroreceptor reflex function in borderline hypertensive rats.
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临界高血压大鼠的动脉压力感受器反射功能。
DOI：
10.1161/01.hyp.19.1.56
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Jones,SY
中科院分区：
文献类型：
--
作者：
DiBona,GF;Jones,SY
随着饮食中氯化钠摄入量的增加（8%氯化钠），临界高血压大鼠会出现高血压，从而表现出自发性高血压亲代的表型。由于自发性高血压父母的动脉压力感受器反射功能受损，因此本研究的目的是检查因饮食中氯化钠摄入量增加而导致高血压的临界高血压大鼠的动脉压力感受器反射功能。边缘性高血压大鼠从 4 周龄到 16 周龄期间饲喂 1% 或 8% NaCl。与饲喂 1% NaCl 的临界高血压大鼠 (n = 11) 相比，饲喂 8% NaCl 的临界高血压大鼠 (n = 10) 患有高血压（141 +/- 3 与 120 +/- 4 mm Hg，p 小于 0.01）。他们长期使用仪器记录动脉压、心率和肾交感神经活动。在有意识的自由活动的动物中测量由于动脉压增加（去氧肾上腺素）和减少（硝化甘油）导致的心率和肾交感神经活动与控制的百分比变化。关于心率的动脉压力感受器反射控制，8% NaCl 临界高血压大鼠具有与 1% NaCl 临界高血压大鼠相似的范围（75 +/- 4%）和最大增益（-2.72 +/- 0.24%/mm Hg）（70 +/- 4%；-2.78 +/- 0.50%/mm Hg）。关于肾交感神经活动的动脉压力感受器反射控制，8% NaCl 临界高血压大鼠的范围值 (205 +/- 22%) 和最大增益 (-3.92 +/- 0.93%/mm Hg) 与 1% NaCl 临界高血压大鼠的值 (167 +/- 33%、-2.76 +/- 0.62%/mm Hg) 没有显着差异。 汞）。（摘要截断为 250 字）
With increased dietary NaCl intake (8% NaCl), the borderline hypertensive rat develops hypertension, thus expressing the phenotype of the spontaneously hypertensive parent. Since arterial baroreceptor reflex function is impaired in the spontaneously hypertensive parent, it was the objective of this study to examine arterial baroreceptor reflex function in the borderline hypertensive rat made hypertensive by increased dietary NaCl intake. Borderline hypertensive rats were fed either 1% or 8% NaCl from age 4 to 16 weeks. Borderline hypertensive rats fed 8% NaCl (n = 10) were hypertensive compared with borderline hypertensive rats fed 1% NaCl (n = 11) (141 +/- 3 versus 120 +/- 4 mm Hg, p less than 0.01). They were chronically instrumented for the recording of arterial pressure, heart rate, and renal sympathetic nerve activity. The percent change from control in heart rate and renal sympathetic nerve activity resulting from increases (phenylephrine) and decreases (nitroglycerine) in arterial pressure were measured in conscious freely moving animals. With respect to arterial baroreceptor reflex control of heart rate, 8% NaCl borderline hypertensive rats had a similar range (75 +/- 4%) and maximal gain (-2.72 +/- 0.24%/mm Hg) as 1% NaCl borderline hypertensive rats (70 +/- 4%; -2.78 +/- 0.50%/mm Hg). With respect to arterial baroreceptor reflex control of renal sympathetic nerve activity, 8% NaCl borderline hypertensive rats had values for range (205 +/- 22%) and maximal gain (-3.92 +/- 0.93%/mm Hg) that were not significantly different from those for 1% NaCl borderline hypertensive rats (167 +/- 33%, -2.76 +/- 0.62%/mm Hg).(ABSTRACT TRUNCATED AT 250 WORDS)
叶酰聚谷氨酸合成酶和γ-谷氨酰水解酶在改变细胞叶酰和抗叶酰聚谷氨酸中的作用。
DOI：
10.1016/0065-2571(87)90011-2
发表时间：
1987
期刊：
Advances in enzyme regulation
影响因子：
--
作者：
Galivan,J;Johnson,T;Rhee,M;McGuire,JJ;Priest,D;Kesevan,V
通讯作者：
Kesevan,V
亲脂性抗叶酸剂曲美曲沙的生化药理学。
DOI：
10.1016/0065-2571(84)90014-1
发表时间：
1984
期刊：
Advances in enzyme regulation
影响因子：
--
作者：
R. Jackson;D. W. Fry;T. Boritzki;J. Besserer;W. Leopold;B. Sloan;E. Elslager
通讯作者：
E. Elslager