Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: a cross-sectional study in patients hospitalized with acute heart failure.
Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: a cross-sectional study in patients hospitalized with acute heart failure.
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DOI：
10.1186/s12968-016-0228-3
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发表时间：
2016-02-05
期刊：
影响因子：
--
通讯作者：
Ng KK
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作者：
Liao PA;Lin G;Tsai SY;Wang CH;Juan YH;Lin YC;Wu MT;Yang LY;Liu MH;Chang TC;Lin YC;Huang YC;Huang PC;Wang JJ;Ng SH;Ng KK
心肌甘油三酯（TG）含量升高已被认为是心血管疾病的危险因素。然而，其与急性心力衰竭（HF）恢复患者心功能的关系仍不清楚。在这项横断面研究中，我们试图探讨因心衰住院患者的磁共振波谱 (1H-MRS) 测量的心肌 TG 含量与心血管磁共振 (CMR) 评估的左心室 (LV) 功能之间的关联。该研究共纳入了 50 名因急性心力衰竭住院后出院的患者和 21 名年龄和性别匹配的对照者。在 3.0 T MR 扫描仪上测量心肌 TG 含量和 LV 参数（功能和质量）。使用 LC 模型算法将脂肪酸 (FA) 和不饱和脂肪酸 (UFA) 含量相对于水 (W) 进行标准化。根据左心室射血分数（LVEF，<50% 或 ≥ 50%）将患者群体分为两类。 48 名患者和 21 名对照者的 H-MRS 数据可用。在 48 名患者中，25 名 LVEF <50%（平均 31.2%），而其余 23 名 LVEF 正常（平均 60.2%）。研究发现，低 LVEF 患者、正常 LVEF 患者和对照组的心肌 UFA/W 比值存在显着差异（分别为 0.79%、0.21% 和 0.14%，p = 0.02）。心肌UFA/TG比值与左心室质量相关（r = 0.39，p < 0.001），与左心室舒张末期容积适度相关（LVEDV；r = 0.24，p = 0.039）。我们还发现心肌 FA/TG 比值与 LV 质量 (r = -0.39, p < 0.001) 和 LVEDV (r = -0.24, p = 0.039) 呈负相关。与对照组相比，因急性心力衰竭住院后出院的患者心肌UFA含量升高；此外，UFA 与 LVEF、LV 质量以及较小程度上的 LVEDV 呈负相关。我们的研究可能会刺激进一步研究通过 1H-MRS 测量心肌 UFA 含量以预测结果。 ClinicalTrial.gov：NCT02378402。注册日期：2015 年 2 月 27 日本文的在线版本 (doi:10.1186/s12968-016-0228-3) 包含补充材料，可供授权用户使用。
Increased myocardial triglyceride (TG) content has been recognized as a risk factor for cardiovascular disease. However, its relation with cardiac function in patients on recovery from acute heart failure (HF) remains unclear. In this cross-sectional study, we sought to investigate the association between myocardial TG content measured on magnetic resonance spectroscopy (1H-MRS) and left ventricular (LV) function assessed on cardiovascular magnetic resonance (CMR) in patients who were hospitalized with HF. A total of 50 patients who were discharged after hospitalization for acute HF and 21 age- and sex-matched controls were included in the study. Myocardial TG content and LV parameters (function and mass) were measured on a 3.0 T MR scanner. Fatty acid (FA) and unsaturated fatty acid (UFA) content was normalized against water (W) using the LC-Model algorithm. The patient population was dichotomized according to the left ventricular ejection fraction (LVEF, <50 % or ≥ 50 %). H-MRS data were available for 48 patients and 21 controls. Of the 48 patients, 25 had a LVEF <50 % (mean, 31.2 %), whereas the remaining 23 had a normal LVEF (mean, 60.2 %). Myocardial UFA/W ratio was found to differ significantly in patients with low LVEF, normal LVEF, and controls (0.79 % vs. 0.21 % vs. 0.14 %, respectively, p = 0.02). The myocardial UFA/TG ratio was associated with LV mass (r = 0.39, p < 0.001) and modestly related to LV end-diastolic volume (LVEDV; r = 0.24, p = 0.039). We also identified negative correlations of the myocardial FA/TG ratio with both LV mass (r = -0.39, p < 0.001) and LVEDV (r = -0.24, p = 0.039). As compared with controls, patients who were discharged after hospitalization for acute HF had increased myocardial UFA content; furthermore, UFA was inversely related with LVEF, LV mass and, to a lesser extent, LVEDV. Our study may stimulate further research on the measure of myocardial UFA content by 1H-MRS for outcome prediction. ClinicalTrial.gov: NCT02378402. Registered 27/02/2015 The online version of this article (doi:10.1186/s12968-016-0228-3) contains supplementary material, which is available to authorized users.