Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary-artery bypass: a controlled, randomized study.
Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary-artery bypass: a controlled, randomized study.
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抗血小板和抗凝治疗未能改善冠状动脉搭桥术后移植物的通畅：一项对照、随机研究。
DOI：
10.1056/nejm197911013011803
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
Josef Rösch
中科院分区：
文献类型：
--
作者：
G. Pantely;S. H. Goodnight;S. H. Goodnight;Shahbudin H. Rahimtoola;Shahbudin H. Rahimtoola;B. Harlan;B. Harlan;H. Demots;H. Demots;L. Calvin;L. Calvin;Josef Rösch
50例接受冠状动脉大隐静脉旁路移植术的患者被随机分为三组，以确定抗血小板或抗凝治疗对移植物通畅性的影响。24例患者作为对照组; 13例患者接受阿司匹林（325 mg，每日3次）和潘生丁（75 mg，每日3次）; 13例患者接受严格控制的华法林治疗。在术后第三天开始用药。术后6个月，所有患者均接受冠状动脉造影以评估移植物通畅性。两组在各种临床、血流动力学和血管造影方面无统计学显著差异，阿司匹林和潘生丁组33例移植物中有27例（82%），华法林组37例移植物中有29例（78%）（P <0.5），所有患者均至少有一个通畅的移植物。术后用阿司匹林和潘生丁或华法林治疗均未能改善移植物的通畅性。
Fifty patients who underwent aortocoronary saphenous-vein bypass-graft surgery were randomly assigned to one of three groups to determine the effects of antiplatelet or anticoagulant therapy on graft patency. Twenty-four patients served as controls; 13 patients received aspirin (325 mg three times a day) and dipyridamole (75 mg three times a day); and 13 patients received closely regulated warfarin therapy. Medications were begun on the third post-operative day. Six months after surgery, all patients underwent coronary angiography to assess graft patency. There were no statistically significant differences between groups in various clinical, hemodynamic and angios, 27 of 33 grafts (82 per cent) with aspirin and dipyridamole and 29 of 37 grafts (78 per cent) with warfarin (P less than 0.5), all patients had at least one patent graft. Postoperative treatment either with aspirin and dipyridamole or with warfarin failed to improve the patency of the grafts.