Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits.
Posterior cingulate gyrus metabolic changes in chronic schizophrenia with generalized cognitive deficits.
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DOI：
10.1016/j.jpsychires.2005.04.015
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发表时间：
2007
影响因子：
4.8
通讯作者：
E. Shimizu;K. Hashimoto;S. Ochi;Goro Fukami;M. Fujisaki;Kaori Koike;Naoe Okamura;Shintaro Ohgake;Hiroki Koizumi;D. Matsuzawa;Lin Zhang;H. Watanabe;M. Nakazato;N. Shinoda;N. Komatsu;F. Morita;M. Iyo
中科院分区：
文献类型：
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作者：
E. Shimizu;K. Hashimoto;S. Ochi;Goro Fukami;M. Fujisaki;Kaori Koike;Naoe Okamura;Shintaro Ohgake;Hiroki Koizumi;D. Matsuzawa;Lin Zhang;H. Watanabe;M. Nakazato;N. Shinoda;N. Komatsu;F. Morita;M. Iyo
已知N-甲基-d-天冬氨酸（NMDA）受体拮抗剂在人类中诱导精神分裂症样精神病症状和认知缺陷，并且已显示在啮齿动物的后扣带回（PCG）中引起神经元损伤。慢性精神分裂症患者表现出广泛的认知功能障碍，但目前尚不清楚PCG是否与他们的认知功能障碍有关。为了确定慢性精神分裂症患者的PCG可能发生什么样的生化变化，并确定这种异常是否可能与认知缺陷的发生率有关，我们获得了19例精神分裂症患者和18名年龄和性别匹配的正常健康对照者的PCG和左右内侧颞叶（MTL）的认知评分和质子磁共振波谱（MRS）。与正常对照组相比，慢性精神分裂症患者在言语和视觉记忆测试、言语流畅性测试和连线测试中的认知表现明显较差。PCG中N-乙酰天冬氨酸与肌酸及磷酸肌酸的比值（NAA/Cr）明显低于对照组。此外，NAA/Cr在PCG的健康对照组表现出与年龄相关的下降，而在精神分裂症患者，相应的值始终较低，无论年龄。因此，这些发现与目前关于PCG神经元功能障碍的推测雅阁，该推测基于关于慢性精神分裂症病理生理学的NMDA功能减退假说。
N-Methyl-d-aspartate (NMDA) receptor antagonists are known to induce schizophrenia-like psychotic symptoms and cognitive deficits in humans, and have been shown to cause neuronal damage in the posterior cingulate gyrus (PCG) of rodents. Patients with chronic schizophrenia exhibit generalized cognitive deficits, but it remains unclear whether or not the PCG is related to their cognitive dysfunction. To determine what biochemical changes may occur in the PCG of patients with chronic schizophrenia, and to ascertain whether or not such abnormalities may be related to the incidence of cognitive deficits, we obtained cognitive scores and proton magnetic resonance spectra (MRS) from the PCG and the left and right medial temporal lobes (MTL) of 19 patients with schizophrenia and 18 age- and sex-matched normal healthy controls. Compared to the normal controls, the patients with chronic schizophrenia showed significantly worse cognitive performance on verbal and visual memory tests, verbal fluency tests, and the Trail Making Test. The ratio of N-acetylaspartate to creatine and phosphocreatine (NAA/Cr) in the PCG of the patients was significantly lower than that of the controls. Moreover, the NAA/Cr in the PCG of the healthy controls exhibited age-related decline, whereas in the patients with schizophrenia, the corresponding values were consistently low, regardless of age. These findings are thus in accord with current speculation about neuronal dysfunction in the PCG based on the NMDA hypofunction hypothesis regarding the pathophysiology of chronic schizophrenia.