Application of inkjet printing to tissue engineering
Application of inkjet printing to tissue engineering
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DOI：
10.1002/biot.200600081
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发表时间：
2006-09-01
影响因子：
4.7
通讯作者：
Cui, Xiaofeng
中科院分区：
文献类型：
--
作者：
Boland, Thomas;Xu, Tao;Cui, Xiaofeng
描述了用于与医疗干预和器官置换相关的应用的器官打印技术的最新进展。器官打印是指将各种细胞类型放置到根据计算机辅助设计模板使用单个设备制造的软支架中。计算机辅助支架拓扑结构设计作为一种可行的选择，以实现组织工程支架内的功能和质量传输要求，最近得到了关注。我们实验室开创的一项令人兴奋的进展是同时打印细胞和生物材料，这使得细胞和蛋白质可以精确地放置在3D水凝胶结构中。这一进步不仅提高了空间控制支架结构的可能性，而且提高了空间控制可以在支架内生长的组织的类型和组织的厚度的可能性，因为毛细血管和血管可以在支架内构建。在这里，我们总结了使用相同设备打印细胞和材料的最新进展。
Recent advances in organ printing technology for applications relating to medical interventions and organ replacement are described. Organ printing refers to the placement of various cell types into a soft scaffold fabricated according to a computer-aided design template using a single device. Computer aided scaffold topology design has recently gained attention as a viable option to achieve function and mass transport requirements within tissue engineering scaffolds. An exciting advance pioneered in our laboratory is that of simultaneous printing of cells and biomaterials, which allows precise placement of cells and proteins within 3-D hydrogel structures. This advance raises the possibility of spatially controlling not only the scaffold structure, but also the type of tissue that can be grown within the scaffold and the thickness of the tissue as capillaries and vessels could be constructed within the scaffolds. Here we summarize recent advances in printing cells and materials using the same device.