Lipid peroxidation in the newborn rat: influence of fasting and hyperoxia on ethane and pentane in expired air.
Lipid peroxidation in the newborn rat: influence of fasting and hyperoxia on ethane and pentane in expired air.
复制标题
新生大鼠的脂质过氧化：禁食和高氧对呼出空气中乙烷和戊烷的影响。
DOI：
10.1159/000457292
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Bucher,JR
中科院分区：
文献类型：
--
作者：
Roberts,RJ;Rendak,I;Bucher,JR
在暴露于空气或高氧（FIO 2> 0.95）的哺乳或禁食新生大鼠中评估脂质过氧化反应速率（通过呼出空气戊烷和乙烷测量确定）。出生后暴露于高氧环境下，哺乳新生大鼠的戊烷和乙烷产生量没有显著变化。3天暴露期内的平均戊烷产量在高氧环境中为2.8 pmol/100 g/min，而在空气中为2.5 pmol/100 g/min。然而，在出生后的前18小时内，禁食的新生大鼠的乙烷产生量显著增加（< 2.5 pmol/100 g/min增加至>6 pmol/100 g/min），而在哺乳动物中未观察到。虽然高氧并没有导致戊烷或乙烷生产高于空气暴露的控制，新生大鼠的营养剥夺似乎加速脂质过氧化反应事件，并导致新生大鼠暴露于高氧的高死亡率。
The rate of lipid peroxidation, as determined by expired air pentane and ethane measurements, was assessed in suckled or fasted newborn rats exposed to air or hyperoxia (FIO2 > 0.95). Pentane and ethane production in suckled newborn rats did not significantly change with exposure to hyperoxia after birth. Pentane production averaged over a 3-day exposure period was 2.8 pmol/100 g/min in hyperoxia versus 2.5 pmol/100 g/min in air. However, significant increases in ethane production occurred in fasted newborn rats over the first 18 h of life (< 2.5 pmol/100 g/min increasing to >6 pmol/100 g/min), which were not observed in suckled animals. Although hyperoxia did not cause an increase in pentane or ethane production above air-exposed controls, nutritional deprivation in newborn rats appeared to accelerate lipid peroxidation events and resulted in high mortality in newborn rats exposed to hyperoxia.