Resting-state functional connectivity in women with Major Depressive Disorder
Resting-state functional connectivity in women with Major Depressive Disorder
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DOI：
10.1016/j.jpsychires.2014.09.002
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发表时间：
2014-12-01
影响因子：
4.8
通讯作者：
Gollan, Jackie K.
中科院分区：
文献类型：
--
作者：
Buchanan, Angel;Wang, Xue;Gollan, Jackie K.
目的：有限的研究集中在目前严重抑郁障碍(MDD)受试者中具有良好特征的样本中的全脑功能连接。我们的目的是研究无合并症的未服用药物的抑郁症患者的静息状态功能连接性及其与抑郁严重程度的相关性。方法：我们利用独立成分分析(ICA)对26名健康对照和20名仅被诊断为当前MDD的未服药患者的全脑功能连接性进行研究。结果：与健康对照组相比，抑郁症患者右额顶叶(p=0.03)、左额顶叶(p=0.01)和语言(p=0.02)神经网络的连接性显著降低。结论：我们在MDD患者中发现了未见报道的静息态功能连接异常。额叶顶叶和语言网络的连通性降低可能代表了抑郁症在注意力、认知控制、目标定向认知和语言方面的困难。这项研究的发现可能会进一步阐明功能连接作为抑郁症严重程度的诊断标志。(C)2014爱思唯尔有限公司。保留所有权利。
Objective: Limited research has focused on whole-brain functional connectivity in a well-characterized sample of subjects with current Major Depressive Disorder (MDD). We aimed to investigate resting-state functional connectivity and the extent to which this is correlated with depression severity in unmedicated depressed subjects without comorbidities.Methods: We utilized Independent Component Analysis (ICA) to investigate whole-brain functional connectivity in a sample of healthy controls (n = 26) and unmedicated subjects diagnosed only with current MDD (n = 20). Correlations were calculated between network connectivity strength and depression severity.Results: Depressed subjects demonstrated significantly decreased connectivity in the right frontoparietal (p = 0.03), left frontoparietal (p = 0.01), and language (p = 0.02) networks compared to healthy control subjects.Conclusion: We found abnormal resting-state functional connectivity not previously reported in MDD. Decreased connectivity in the frontoparietal and language networks may represent depression-related difficulties in attention, cognitive control, goal-directed cognition, and language. Findings from this study may further elucidate functional connectivity as a diagnostic marker of depression severity. (C) 2014 Elsevier Ltd. All rights reserved.