Iron deficiency anemia and depleted body iron reserves are prevalent among pregnant African-American adolescents
Iron deficiency anemia and depleted body iron reserves are prevalent among pregnant African-American adolescents
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DOI：
10.1093/jn/135.11.2572
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发表时间：
2005-11-01
影响因子：
4.2
通讯作者：
Witter, FR
中科院分区：
文献类型：
--
作者：
Iannotti, LL;O'Brien, KO;Witter, FR
贫血在怀孕的青少年中很普遍，但关于这一群体铁状况的生化指标的数据很少。我们假设，在非洲裔美国人的高危人群中，怀孕的青少年，铁的消耗和缺乏的程度将是显着的，缺铁性贫血将包括观察到的贫血的大部分。为了检验这一点，血液样本收集80名女孩（518岁）参加内城妇产科诊所，其中23人进行了纵向研究，在第二和第三孕期取决于在诊所接触。生物标志物的样本量根据试验完成时可用的血容量而变化。描述性统计被用来描述铁状态，多变量回归和逻辑分析被用来确定铁状态的重要决定因素。在孕晚期，铁储备（第2个月的铁蛋白300）耗尽的患者被归类为缺铁性贫血的可能性比那些比率较低的患者高12.5倍（95%CI 2.83，55.25）（P = 0.0002）。在妊娠第26周后检测的受试者体内铁的估计值较低（P < 0.0001），在妊娠第2周和第3周队列中，分别有5.0%和31.3%的受试者体内铁储备耗尽。总之，缺铁性贫血在这些怀孕的少数民族青少年中普遍存在。有针对性的筛查和干预措施，以改善饮食和遵守产前补铁是必要的，这一风险群体。
Anemia is prevalent among pregnant adolescents, but few data exist on biochemical indicators of iron status in this group. We hypothesized that among an at-risk population of African-American, pregnant adolescents, the degree of iron depletion and deficiency would be marked, and that iron deficiency anemia would comprise the majority of the observed anemia. To examine this, blood samples were collected from 80 girls (518 y old) attending an inner city maternity clinic, 23 of whom were studied longitudinally in the 2nd and 3rd trimesters depending on contact at the clinic. Sample sizes for the biomarkers varied according to the blood volume available at the time the assays were completed. Descriptive statistics were applied to characterize iron status, and multivariate regression and logistic analyses were used to identify significant determinants of iron status. Depleted iron stores (ferritin 300 during the 2nd trimester were 12.5 times (95% Cl 2.83, 55.25) more likely to be classified with iron deficiency anemia during the 3rd trimester (P = 0.0002) than those with lower ratios. Estimates of body iron were lower in those tested after wk 26 of gestation (P < 0.0001), and reserves were depleted in 5.0% vs. 31.3% of the 2nd In = 40) and 3rd In = 48) trimester cohorts, respectively. In conclusion, iron-deficiency anemia was prevalent among these pregnant minority adolescents. Targeted screening and interventions to improve diet and compliance with prenatal iron supplementation are warranted for this at-risk group.