Neurovascular photoacoustic tomography.
Neurovascular photoacoustic tomography.
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DOI：
10.3389/fnene.2010.00010
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Wang LV
中科院分区：
文献类型：
--
作者：
Hu S;Wang LV
神经血管偶联是指神经元活动与下游血流动力学反应之间的关系。光声断层成像(PAT)能够以高度可扩展的穿透性和空间分辨率对血流动力学活动进行全面的无标记成像，在神经血管耦合的研究中具有巨大的潜力。在这篇综述中，我们首先介绍了血液动力学PAT的技术基础--包括总血红蛋白浓度、血氧和血流量的无标记定量--以及它在血液动力学监测中的应用。然后，我们通过突出脑血管对胡须刺激和阿尔茨海默病反应的代表性研究，展示了PAT在神经血管成像中的潜在应用。最后，讨论了可能的研究方向和相关的技术挑战。
Neurovascular coupling refers to the relationship between neuronal activities and downstream hemodynamic responses. Photoacoustic tomography (PAT), enabling comprehensive label-free imaging of hemodynamic activities with highly scalable penetration and spatial resolution, has great potential in the study of neurovascular coupling. In this review, we first introduce the technical basis of hemodynamic PAT – including label-free quantification of total hemoglobin concentration, blood oxygenation, and blood flow – as well as its applications in hemodynamic monitoring. Then, we demonstrate the potential application of PAT in neurovascular imaging by highlighting representative studies on cerebral vascular responses to whisker stimulation and Alzheimer's disease. Finally, potential research directions and associated technical challenges are discussed.