Receptors and immune sensors: the complex entry path of human cytomegalovirus
Receptors and immune sensors: the complex entry path of human cytomegalovirus
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DOI：
10.1016/j.tcb.2003.10.009
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发表时间：
2004-01-01
影响因子：
19
通讯作者：
Compton, T
中科院分区：
文献类型：
--
作者：
Compton, T
人巨细胞病毒（HCMV）感染广泛细胞类型的能力使得鉴定这种重要病原体的细胞受体的努力变得复杂。最近的研究表明，表皮生长因子受体（EGFR）也是HCMV的受体。其他证据表明，HCMV进入与通过Toll样受体的免疫检测一致。在这里，表皮生长因子受体激活的影响，其他受体的存在和协调的进入与先天感觉进行了讨论。
The ability of human cytomegalovirus (HCMV) to infect an extensive range of cell types has complicated efforts to identify cellular receptors for this significant pathogen. Recent findings demonstrate that epidermal growth factor receptor (EGFR) serves also as a receptor for HCMV. Additional evidence has shown that HCMV entry occurs in concert with immune detection through toll-like receptors. Here, the implications of EGFR activation, the existence of other receptors and the coordination of entry with the innate sensing are discussed.