Unraveling the Mysteries of PAX8 in Reproductive Tract Cancers.
Unraveling the Mysteries of PAX8 in Reproductive Tract Cancers.
复制标题
揭开 PAX8 在生殖道癌症中的神秘面纱。
DOI：
10.1158/0008-5472.can-20-3173
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发表时间：
2021-02-15
期刊：
影响因子：
11.2
通讯作者：
Drapkin R
中科院分区：
文献类型：
--
作者：
Chaves-Moreira D;Morin PJ;Drapkin R
PAX8是一种谱系特异性转录因子，在胚胎发生和肿瘤发生过程中发挥重要作用。PAX8在生殖系统发育中的重要性通过在该PAX家族成员的丢失或突变后观察到的异常而突出。在癌症中，PAX8表达在一组关键肿瘤中失调，包括苗勒管引起的肿瘤。PAX8在肿瘤发生中的作用是多种多样的，包括表观遗传重塑、刺激增殖、抑制凋亡和调节血管生成。PAX8可以在癌症进展过程中与不同的蛋白质伴侣相互作用，并可能表现出显著的功能改变选择性剪接。此外，PAX8在癌症中的表达也可以作为诊断和预后目的的生物标志物。在这篇综述中，我们重点介绍PAX8在生殖系统癌症中的作用。了解PAX8在发育和肿瘤发生中的不同作用机制可能会发现目前缺乏有效疗法的恶性肿瘤的新弱点。
Paired Box 8 (PAX8) is a lineage-specific transcription factor that has essential roles during embryogenesis and tumorigenesis. The importance of PAX8 in the development of the reproductive system is highlighted by abnormalities observed upon the loss or mutation of this PAX family member. In cancer, PAX8 expression is deregulated in a key set of neoplasms, including those arising from the Müllerian ducts. The roles of PAX8 in oncogenesis are diverse and include epigenetic remodeling, stimulation of proliferation, inhibition of apoptosis, and regulation of angiogenesis. PAX8 can interact with different protein partners during cancer progression and may exhibit significant function-altering alternative splicing. Moreover, expression of PAX8 in cancer can also serve as biomarker for diagnostic and prognostic purposes. In this review, we focus on the roles of PAX8 in cancers of the reproductive system. Understanding the diverse mechanisms of action of PAX8 in development and oncogenesis may identify new vulnerabilities in malignancies that currently lack effective therapies.