Convergence of prefrontal and parietal anatomical projections in a connectional hub in the striatum
Convergence of prefrontal and parietal anatomical projections in a connectional hub in the striatum
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DOI：
10.1016/j.neuroimage.2016.09.037
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发表时间：
2017-02-01
期刊：
影响因子：
5.7
通讯作者：
Haber, Suzanne N.
中科院分区：
文献类型：
--
作者：
Choi, Eun Young;Tanimura, Yoko;Haber, Suzanne N.
视觉注意偏差的形成是为了奖励和惩罚环境中的刺激。虽然这种注意偏差在健康情况下是适应性的，但在药物成瘾或创伤后应激障碍等疾病中是不适应的。在这两种疾病中，控制这种注意偏倚的能力与药物戒断率或减轻创伤后应激障碍症状有关，表明视觉注意、认知控制和刺激关联的相互作用。下顶叶（IPL）是注意力的中心，而前额叶皮层（PFC）对奖励、认知控制和注意力至关重要。重要的是，IPL和PFC区域通常投射到纹状体的吻侧背尾状（rdCaud）。我们提出了一种解剖网络结构，其中IPL投影与PFC投影在rdCaud的连接枢纽中收敛，为这些投影的相互作用及其对纹状体处理的竞争性影响提供了解剖学基础。为了研究这一点，我们在猴子身上注射了解剖道追踪示踪剂，绘制了从尾侧IPL和前额叶（dlPFC、vlPFC、OFC、dACC和dmPFC）区域投射到内侧rdCaud的密集投影。这些输入集中在内侧背的一个精确位置，即前连合的吻侧。少量逆行示踪剂注射证实了这些输入到内侧脑皮层，并表明近侧腹纹状体位置具有非常不同的皮层输入模式。接下来，我们使用人类静息状态功能连接MRI （fcMRI）来检查纹状体中枢是否存在于人类内侧脑皮层中。人类内侧脑皮层的种子区显示了与猴子逆行注射结果相似的皮质相关图。随后对这些相关皮质区域的分析表明，纹状体内它们的相关性最高的区域在内侧内侧，这表明这是一个连接中枢。相反，纹状体相关的峰值在腹侧纹状体位置没有发现，这表明该位置不是皮质区域的连接枢纽。综上所述，这项工作利用猴子解剖结构的精确性，确定了内侧视网膜中IPL和PFC投射的连接枢纽。它还将这种解剖学上的精确性转化为人类，证明在解剖学的指导下，连接枢纽可以用功能性磁共振成像识别人类。这些连接中枢为药物成瘾、创伤后应激障碍和其他涉及纹状体的神经和精神疾病提供了更具体的治疗目标。
Visual attentional bias forms for rewarding and punishing stimuli in the environment. While this attentional bias is adaptive in healthy situations, it is maladaptive in disorders such as drug addiction or PTSD. In both these disorders, the ability to exert control over this attentional bias is associated with drug abstinence rates or reduced PTSD symptoms, indicating the interaction of visual attention, cognitive control, and stimulus association. The inferior parietal lobule (IPL) is central to attention, while the prefrontal cortex (PFC) is critical for reward, cognitive control, and attention. Importantly, regions of the IPL and PFC commonly project to the rostral dorsal caudate (rdCaud) of the striatum. We propose an anatomical network architecture in which IPL projections converge with PFC projections in a connectional hub in the rdCaud, providing an anatomical substrate for the interaction of these projections and their competitive influence on striatal processing. To investigate this, we mapped the dense projections from the caudal IPL and prefrontal (dlPFC, vlPFC, OFC, dACC, and dmPFC) regions that project to the medial rdCaud with anatomical tract-tracing tracer injections in monkeys. These inputs converge in a precise site in the medial rdCaud, rostral to the anterior commissure. Small retrograde tracer injections confirmed these inputs to the medial rdCaud and showed that a proximal ventral striatal location has a very different pattern of cortical inputs. We next used human resting-state functional connectivity MRI (fcMRI) to examine whether a striatal hub exists in the human medial rdCaud. Seed regions in the human medial rdCaud revealed cortical correlation maps similar to the monkey retrograde injection results. A subsequent analysis of these correlated cortical regions showed that their peak correlation within the striatum is in the medial rdCaud, indicating that this is a connectional hub. In contrast, this peak striatal correlation was not found in the ventral striatal location, suggesting that this site is not a connectional hub of cortical regions. Taken together, this work uses the precision of monkey anatomy to identify a connectional hub of IPL and PFC projections in the medial rdCaud. It also translates this anatomical precision to humans, demonstrating that, guided by anatomy, connectional hubs can be identified in humans with fcMRI. These connectional hubs provide more specific treatment targets for drug addiction, PTSD, and other neurological and psychiatric disorders involving the striatum.