Highly sensitive detection of cancer cells by electrochemical impedance spectroscopy
Highly sensitive detection of cancer cells by electrochemical impedance spectroscopy
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DOI：
10.1016/j.electacta.2011.11.112
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发表时间：
2012-02-01
影响因子：
6.6
通讯作者：
Ma, Zhanfang
中科院分区：
文献类型：
--
作者：
Wang, Ruimin;Di, Jing;Ma, Zhanfang
利用叶酸功能化纳米金修饰的金电极，建立了一种基于电化学阻抗谱的高灵敏度检测富含叶酸受体的HeLa细胞的简单方法。该传感器在6×10(0)~1×10(3)和1×10(3)~1×10(5)细胞(-1)两种浓度范围内呈良好的线性关系。对HeLa细胞的检出限为6细胞毫升(-1)。该方法在癌症早期诊断中的应用具有重要意义。(C)2011爱思唯尔有限公司。保留所有权利。
A simple method based on electrochemical impedance spectroscopy using a gold electrode modified with folic acid-functionalized gold nanoparticles was used to detect folate receptor-rich HeLa cells with high sensitivity. The electrochemical impedance of the cytosensor was linear in two concentration ranges of HeLa cells, ranging from 6 x 10(0) to 1 x 10(3) and 1 x 10(3) to 1 x 10(5) cells mL(-1). The detection limit for HeLa cells was 6 cells mL(-1). This method could be significant for future applications in early stage cancer diagnosis. (C) 2011 Elsevier Ltd. All rights reserved.