Activity of Amphotericin B, 5-Fluorocytosine, and Rifampin Against Six Clinical Isolates of Aspergillus
Activity of Amphotericin B, 5-Fluorocytosine, and Rifampin Against Six Clinical Isolates of Aspergillus
复制标题
两性霉素 B、5-氟胞嘧啶和利福平对六种曲霉菌临床分离株的活性
DOI：
10.1128/aac.9.6.915
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发表时间：
1976
影响因子：
4.9
通讯作者：
George S. Kobayashi
中科院分区：
文献类型：
--
作者：
M. Kitahara;V. K. Seth;Gerald Medoff;George S. Kobayashi
两性霉素B联合5-氟胞嘧啶对烟曲霉的三种临床分离株和A.黄的两性霉素B与利福平联合对所有六种测试的曲霉菌临床分离株具有协同作用。协同作用所需的5-氟胞嘧啶和利福平的水平高于临床上可达到的浓度时，协同作用的测量是基于视觉浊度，但当药物的影响是通过抑制核糖核酸合成或干重增加，低得多的浓度是有效的。
Amphotericin B in combination with 5-fluorocytosine was synergistic against three clinical isolates of Aspergillus fumigatus and one of three clinical isolates of A. flavus. Amphotericin B in combination with rifampin was synergistic against all six clinical isolates of Aspergillus tested. The levels of 5-fluorocytosine and rifampin required for synergism were higher than clinically achievable concentrations when measurements of synergism were based on visual turbidity; but when the effects of the drugs were measured by inhibition of ribonucleic acid synthesis or dry-weight increase, much lower concentrations were effective.