Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans
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DOI：
10.1016/s0304-3940(01)02514-9
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发表时间：
2002-02-08
影响因子：
2.5
通讯作者：
Smith, MA
中科院分区：
文献类型：
--
作者：
Castellani, RJ;Perry, G;Smith, MA
多种证据表明，氧化应激是帕金森病（PD）和弥漫性路易体病（DLBD）的重要致病因素。以前，我们证明了路易体中氧化还原活性铁水平的增加，以及路易体积累晚期糖基化终产物。为了进一步表征氧化应激在路易体形成疾病中的作用，我们对8例PD和5例DLBD的脂质过氧化加合物4-羟基-2-壬烯醛加合物和N-α-（羧甲基）赖氨酸（CIVIL）进行了免疫细胞化学检查。我们的研究结果表明，4-羟基壬烯醛和CML的路易体在PD和DLBD的免疫定位。这些发现不仅支持先前的研究表明，脂质过氧化作用增加的PD和DLBD患者，但氧化损伤可能在路易体形成中发挥关键作用。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Multiple lines of evidence indicate that oxidative stress is a critical pathogenic factor in Parkinson disease (PD) and diffuse Lewy body disease (DLBD). Previously, we demonstrated increased levels of redox-active iron in Lewy bodies, and that Lewy bodies accumulate advanced glycation end-products. To further characterize the role of oxidative stress in diseases with Lewy body formation, we examined immunocytochemically eight cases of PD and five cases of DLBD for adducts of the lipid peroxidation adduct 4-hydroxy-2-nonenal, and for N-epsilon-(carboxymethyl) lysine (CIVIL). Our findings demonstrate immunolocalization of 4-hydroxynonenal and CML to Lewy bodies in PD and DLBD. These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.