Cytotoxic constitutents from Cryptocarya maclurei
Cytotoxic constitutents from Cryptocarya maclurei
复制标题
厚壳桂细胞毒性成分
DOI：
10.1016/j.phytochem.2013.01.009
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发表时间：
2013-06-01
期刊：
影响因子：
3.8
通讯作者：
Ge, Hui Ming
中科院分区：
文献类型：
--
作者：
Feng, Rui;Wang, Ting;Ge, Hui Ming
通过对厚壳桂的植物化学研究，分离出五种黄烷酮，隐子香酮G-H和一种聚酮化合物，隐子香酮。通过1D和2D NMR数据分析鉴定了分离物的结构，并通过CD方法确定了它们的绝对构型。提出了一个推测的生物合成途径。评价这些化合物对KB、SGC-7901和SW 1116癌细胞系的细胞毒性，只有cryptomaclurone显示中等细胞毒性（IC 50分别为28.2、28.4和16.4 μ M）。(C)2013爱思唯尔有限公司保留所有权利。
A phytochemical study of Cryptocarya maclurei led to isolation of five flavanones, cryptogiones G-H, and a polyketide, cryptomaclurone. The structures of the isolates were elucidated by analysis of the 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by CD methods. A putative biosynthetic pathway to them is proposed. Cytotoxicity of these compounds evaluated against KB, SGC-7901 and SW 1116 cancer cell lines, with only cryptomaclurone exhibiting moderate cytotoxicity (IC50 28.2, 28.4 and 16.4 mu M, respectively). (C) 2013 Elsevier Ltd. All rights reserved.