Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.
Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.
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DOI：
10.1155/2010/986596
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发表时间：
2010
影响因子：
4.6
通讯作者：
Lenert PS
中科院分区：
文献类型：
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作者：
Lenert PS
我们的免疫防御依赖于两支专门的武装部队。先天力作为一种警报机制，通过toll样受体（TLR）和NOD蛋白对共同微生物模式的识别来感知微环境的变化。它迅速产生炎症反应，目的是在粘膜检查点中和入侵者。先天手臂也与更专门的适应性力量（以病原体特异性B细胞和T细胞为代表）交流这一信息。有趣的是，B细胞也表达一些天生的传感器，如TLR7和TLR9，并可能对细菌低甲基化的CpG基序和单链RNA病毒作出反应。细胞内核酸传感TLRs在系统性红斑狼疮（SLE）发病机制中起重要作用。在这篇综述中，我们描述了基于寡核苷酸（ODN）的TLR9和/或TLR7信号抑制剂的最新进展。我们根据它们的细胞和分子靶点将这些新疗法分为G、R和B类。一些短的odn已经显示出作为动物狼疮途径特异性治疗的希望。我们展望其未来在人类SLE、微生物dna依赖性败血症和其他自身炎症性疾病中的应用。
Our immune defense depends on two specialized armed forces. The innate force acts as an alarm mechanism that senses changes in the microenvironment through the recognition of common microbial patterns by Toll-like receptors (TLR) and NOD proteins. It rapidly generates an inflammatory response aimed at neutralizing the intruder at the mucosal checkpoint. The innate arm also communicates this message with more specialized adaptive forces represented by pathogen-specific B cells and T cells. Interestingly, B cells also express some innate sensors, like TLR7 and TLR9, and may respond to bacterial hypomethylated CpG motifs and single-stranded RNA viruses. Intracellular nucleic acid sensing TLRs play an important role in the pathogenesis of Systemic Lupus Erythematosus (SLE). In this review, we describe recent achievements in the development of oligonucleotide—(ODN)-based inhibitors of TLR9 and/or TLR7 signaling. We categorize these novel therapeutics into Classes G, R, and B based on their cellular and molecular targets. Several short ODNs have already shown promise as pathway-specific therapeutics for animal lupus. We envision their future use in human SLE, microbial DNA-dependent sepsis, and in other autoinflammatory diseases.
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影响因子：
4.4
作者：
Gursel, I;Gursel, M;Klinman, DM
通讯作者：
Klinman, DM
影响因子：
3.1
作者：
Cortez-Gonzalez, Xochitl;Pellicciotta, Ilenia;Zanetti, Maurizio
通讯作者：
Zanetti, Maurizio
影响因子：
4.4
作者：
Gorden, Keith K. B.;Qiu, Xiaohong;Alkan, Sefik S.
通讯作者：
Alkan, Sefik S.
影响因子：
4.8
作者：
Bianchi, A;de Lange, T
通讯作者：
de Lange, T
影响因子：
64.5
作者：
通讯作者：
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