Reversal by vasopressin of intractable hypotension in the late phase of hemorrhagic shock
Reversal by vasopressin of intractable hypotension in the late phase of hemorrhagic shock
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DOI：
10.1161/01.cir.100.3.226
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发表时间：
1999-07-20
期刊：
影响因子：
37.8
通讯作者：
Landry, DW
中科院分区：
文献类型：
--
作者：
Morales, D;Madigan, J;Landry, DW
背景：严重程度和持续时间明显的低血容量性休克可能进展为心血管衰竭，对容量替代和药物干预无反应。在临床观察的基础上，我们研究了抗利尿激素在这种疾病的动物模型中的作用。方法与结果：将7只狗放血入储血池，引起延长性失血性休克（平均动脉压[MAP]约40 mm Hg）。大约30分钟后，需要逐步回输以将MAP维持在大约40 mm Hg，大约1小时后，尽管血容量完全恢复，仍需要给药约3 μ g的去甲肾上腺素。公斤(1)。需要最小（-1）来维持这个压力。此时给药抗利尿激素1 ~ 4 mU。公斤(1)。min（-1）使MAP从39+/-6增加到128+/-9 mm Hg
Background-Hypovolemic shock of marked severity and duration may progress to cardiovascular collapse unresponsive to volume replacement and drug intervention. On the basis of clinical observations, we investigated the action of vasopressin in an animal model of this condition.Methods and Results-In 7 dogs, prolonged hemorrhagic shock (mean arterial pressure [MAP] of approximate to 40 mm Hg) was induced by exsanguination into a reservoir. After approximate to 30 minutes, progressive reinfusion was needed to maintain MAP at approximate to 40 mm Hg, and by approximate to 1 hour, despite complete restoration of blood volume, the administration of norepinephrine approximate to 3 mu g . kg(-1) . min(-1) was required to maintain this pressure. At this moment, administration of vasopressin 1 to 4 mU . kg(-1) . min(-1) increased MAP from 39+/-6 to 128+/-9 mm Hg (P