INACTIVATION OF SOME ANIMAL VIRUSES WITH GAMMA RADIATION FROM COBALT-60
INACTIVATION OF SOME ANIMAL VIRUSES WITH GAMMA RADIATION FROM COBALT-60
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DOI：
10.3181/00379727-91-22215
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发表时间：
1956-01-01
影响因子：
--
通讯作者：
KEMPE, LL
中科院分区：
文献类型：
--
作者：
JORDAN, RT;KEMPE, LL
研究了伽马辐射对体外4种动物病毒的影响。选取兰辛脊髓灰质炎病毒作为小病毒的代表，选取圣路易斯脑炎和西部马脑脊髓炎病毒作为中型病毒，选取牛痘病毒作为大型病毒。来自Co-60的伽马射线被证明是一种有效的灭活所有测试病毒的方法。部分纯化的病毒悬浮液比原始的病毒悬浮液更容易受到伽马辐射的致命影响。在粗制和部分纯化的悬浮液中，较小的病毒比较大的病毒需要更大剂量的伽马辐射来灭活。在实验误差范围内，被测试病毒的失活率是伽马辐射剂量的指数函数。
Studies were undertaken to investigate the effect of gamma radiation on 4 animal viruses in vitro. The Lansing poliomyelitis virus was selected as representative of a small virus, St. Louis encephalitis and Western equine encephalomyelitis viruses were chosen to represent medium sized viruses and vaccinia a large virus. Gamma radiation from Co-60 proved to be an effective method for the inactivation of all viruses tested. Partially purified suspensions of the viruses used were more vulnerable to the lethal effects of gamma radiation than were crude suspensions. In crude and partially purified suspensions the smaller viruses required larger doses of gamma radiation for inactivation than did the larger viruses. The rate of inactivation for the viruses tested, within error of the experiment, was an exponential function of the dosage of gamma radiation.