Neuroleptic bioavailability, psychosocial factors, and clinical status: A 1-year study of schizophrenic outpatients after dose reduction
Neuroleptic bioavailability, psychosocial factors, and clinical status: A 1-year study of schizophrenic outpatients after dose reduction
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抗精神病药物的生物利用度、心理社会因素和临床状态：一项针对精神分裂症门诊患者减少剂量后的一年研究
DOI：
10.1016/0165-1781(86)90124-1
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发表时间：
1986
影响因子：
11.3
通讯作者：
W. Brown
中科院分区：
文献类型：
--
作者：
S. Faraone;J. Curran;T. Laughren;F. Faltus;R. Johnston;W. Brown
对29例临床确定的抗精神病药剂量减少50%的精神分裂症门诊患者进行1年的血清抗精神病药水平、催乳素水平和临床状态评估。55%的受试者保持稳定。复发和稳定患者的抗精神病药剂量无差异。减量后2周的血清催乳素（PRL）和减量后的平均PRL在复发患者中显著降低。氟哌啶醇治疗的复发患者血清抗精神病药水平明显降低。在复发患者中，血清PRL和抗精神病药水平在稳定期和复发期之间没有差异。在抗精神病药生物利用度相对较低的患者中，与稳定的患者相比，复发患者的社交活动水平较低，社交网络更不愉快，更令人厌恶，更没有帮助。
Serum neuroleptic levels, prolactin levels, and clinical state were assessed for 1 year in 29 schizophrenic outpatients whose clinically determined neuroleptic dose had been reduced by 50%. Fifty-five percent of the subjects remained stable. Neuroleptic dose did not differ between relapsed and stable patients. Serum prolactin (PRL) assessed 2 weeks after dose reduction and mean PRL after reduction were significantly lower among relapsers. Serum neuroleptic levels were significantly lower for relapsers in patients on haloperidol. Among relapsers, there were no serum PRL or neuroleptic level differences between stable periods and the relapse episode. Among patients with relatively low neuroleptic bioavailability, relapsers reported lower levels of social activity and had social networks that were less enjoyable, more aversive, and less helpful than those of stable patients.
父母的情感方式与精神分裂症的治疗。
影响因子：
--
作者：
Doane,JA;Falloon,IR;Goldstein,MJ;Mintz,J
通讯作者：
Mintz,J