Methylxanthines reverse the adipsic and aphagic syndrome induced by bilateral 6-hydroxydopamine lesions of the nigrostriatal pathway in rats
Methylxanthines reverse the adipsic and aphagic syndrome induced by bilateral 6-hydroxydopamine lesions of the nigrostriatal pathway in rats
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DOI：
10.1016/s0091-3057(00)00189-1
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发表时间：
2000-06-01
影响因子：
3.6
通讯作者：
Jané, F
中科院分区：
文献类型：
--
作者：
Casas, M;Prat, G;Jané, F
本研究调查了甲基黄嘌呤（咖啡因和茶碱）是否会恢复因黑质纹状体束双侧 6-羟基多巴胺损伤而导致失食和无食的大鼠的食物和水摄入量，并将这些结果与 d-苯丙胺、多巴胺 D-1 激动剂 SKF 38393 和 D-2/3 激动剂喹吡罗的作用进行比较。在另一项实验中，我们研究了选择性 D-1 拮抗剂 SCH 23390 或选择性 D-2 拮抗剂舒必利是否会阻止双侧 6-羟基多巴胺去神经大鼠的咖啡因诱导的食物和水摄入恢复。结果表明，咖啡因？茶碱和喹吡罗显着逆转了病变动物中观察到的吞咽困难和食欲不振。 SKF 38393 对水摄入量没有显着影响，但在最高剂量下可显着恢复食物摄入量。相比之下，d-苯丙胺对食物或水的摄入量没有显着影响。第二个实验的结果表明，与 SCH 23390 相比，舒必利在更大程度上减弱了咖啡因诱导的损伤大鼠食物和水摄入量的恢复。这些数据表明，甲基黄嘌呤可能通过作用于多巴胺能系统来介导其对双侧 6-羟基多巴胺损伤大鼠的食物和水摄入量的影响。 (C) 2000 爱思唯尔科学公司。
This study investigated whether methylxanthines (caffeine and theophylline) would restore food and water intake in rats made aphagic and adipsic by bilateral 6-hydroxydopamine lesions of, the nigrostriatal bundle, and these results were compared with the effects of d-amphetamine, the dopamine D-1 agonist SKF 38393, and the D-2/3 agonist quinpirole. In a separate experiment, we investigated whether the selective D-1 antagonist, SCH 23390, or the selective D-2 antagonist, sulpiride, would prevent the caffeine-induced restoration of food and water intake in bilaterally 6-hydroxydopamine denervated rats. The results showed that caffeine? theophylline, and quinpirole significantly reversed the aphagia and adipsia observed in lesioned animals. SKF 38393 had no significant effects on water intake, while it significantly restored food intake at the highest dose used. In contrast, d-amphetamine had no significant effects on food or water intake. Results from the second experiment showed that sulpiride attenuated the caffeine-induced restoration of food and water intake in lesioned rats to a greater extent than did SCH 23390. These data suggest that methylxanthines may mediate their effects on food and water intake in bilateral 6-hydroxydopamine-lesioned rats through an action at the dopaminergic system. (C) 2000 Elsevier Science Inc.